Spinal multiparametric MRI and DEXA changes over time in men with prostate cancer treated with androgen deprivation therapy: a potential imaging biomarker of treatment toxicity

Martin, Jarad, Arm, Jameen, Smart, Joanne, Palazzi, Kerrin, Capp, Anne, Ainsworth, Paul and Cowin, Gary (2016) Spinal multiparametric MRI and DEXA changes over time in men with prostate cancer treated with androgen deprivation therapy: a potential imaging biomarker of treatment toxicity. European Radiology, 1-9. doi:10.1007/s00330-016-4434-z


Author Martin, Jarad
Arm, Jameen
Smart, Joanne
Palazzi, Kerrin
Capp, Anne
Ainsworth, Paul
Cowin, Gary
Title Spinal multiparametric MRI and DEXA changes over time in men with prostate cancer treated with androgen deprivation therapy: a potential imaging biomarker of treatment toxicity
Journal name European Radiology   Check publisher's open access policy
ISSN 1432-1084
0938-7994
Publication date 2016-01-01
Year available 2016
Sub-type Article (original research)
DOI 10.1007/s00330-016-4434-z
Open Access Status Not yet assessed
Start page 1
End page 9
Total pages 9
Place of publication Heidelberg, Germany
Publisher Springer Verlag
Collection year 2017
Language eng
Formatted abstract
Objectives

To explore changes in bone mineral density (BMD) measured by DEXA and MRS fat fraction (FF), Dixon FF, and ADC in lower spinal vertebral bodies in men with prostate cancer treated with androgen deprivation therapy (ADT).

Methods

Twenty-eight men were enrolled onto a clinical trial. All received ADT. DEXA imaging was performed at baseline and 12 months. L-spine MRI was done at baseline and 6 months.

Results

The number of patients who underwent DEXA, Dixon, ADC, and MRS at baseline/follow-up were 28/27, 28/26, 28/26, and 22/20. An increase in FF was observed from T11 to S2 (average 1 %/vertebra). There was a positive correlation between baseline MRS FF and Dixon FF (r = 0.85, p < 0.0001) and a negative correlation between MRS FF and ADC (r = -0.56, p = 0.036). Over 6 months, MRS FF increased by a median of 25 % in relative values (p = 0.0003), Dixon FF increased (p < 0.0001) and ADC values decreased (p = 0.0014). Men with >5 % BMD loss after 1 year had triple the percentage increase in MRS FF at 6 months (61.1 % vs. 20.9 %, p = 0.19).

Conclusions

Changes are observed on L-spine MRI after 6 months of ADT. Further investigation is warranted of MRS change as a potential predictive biomarker for later BMD loss.
Keyword Magnetic resonance imagining
Bone density
Prostate neoplasms
Biomarkers
Toxicity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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