What is unconsciousness in a fly or a worm? A review of general anesthesia in different animal models

Zalucki, Oressia and Van Swinderen, Bruno (2016) What is unconsciousness in a fly or a worm? A review of general anesthesia in different animal models. Consciousness and Cognition, 44 72-88. doi:10.1016/j.concog.2016.06.017


Author Zalucki, Oressia
Van Swinderen, Bruno
Title What is unconsciousness in a fly or a worm? A review of general anesthesia in different animal models
Journal name Consciousness and Cognition   Check publisher's open access policy
ISSN 1090-2376
1053-8100
Publication date 2016-08-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.concog.2016.06.017
Open Access Status Not yet assessed
Volume 44
Start page 72
End page 88
Total pages 17
Place of publication Maryland Heights, MO, United States
Publisher Academic Press
Collection year 2017
Language eng
Abstract All animals are rendered unresponsive by general anesthetics. In humans, this is observed as a succession of endpoints from memory loss to unconsciousness to immobility. Across animals, anesthesia endpoints such as loss of responsiveness or immobility appear to require significantly different drug concentrations. A closer examination in key model organisms such as the mouse, fly, or the worm, uncovers a trend: more complex behaviors, either requiring several sub-behaviors, or multiple neural circuits working together, are more sensitive to volatile general anesthetics. This trend is also evident when measuring neural correlates of general anesthesia. Here, we review this complexity hypothesis in humans and model organisms, and attempt to reconcile these findings with the more recent view that general anesthetics potentiate endogenous sleep pathways in most animals. Finally, we propose a presynaptic mechanism, and thus an explanation for how these drugs might compromise a succession of brain functions of increasing complexity.
Keyword Caenorhabditis elegans
Drosophila
Electrophysiology
Isoflurane
Sleep
Synapse
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
 
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