Cognitive and social functioning deficits after anti-N-methyl-D-aspartate receptor encephalitis: an exploratory case series

McKeon, Gemma L., Scott, James G., Spooner, Donna M., Ryan, Alexander E., Blum, Stefan, Gillis, David, Langguth, Daman and Robinson, Gail A. (2016) Cognitive and social functioning deficits after anti-N-methyl-D-aspartate receptor encephalitis: an exploratory case series. Journal of the International Neuropsychological Society, 22 8: 828-838. doi:10.1017/S1355617716000679


Author McKeon, Gemma L.
Scott, James G.
Spooner, Donna M.
Ryan, Alexander E.
Blum, Stefan
Gillis, David
Langguth, Daman
Robinson, Gail A.
Title Cognitive and social functioning deficits after anti-N-methyl-D-aspartate receptor encephalitis: an exploratory case series
Journal name Journal of the International Neuropsychological Society   Check publisher's open access policy
ISSN 1469-7661
1355-6177
Publication date 2016-09-01
Sub-type Article (original research)
DOI 10.1017/S1355617716000679
Open Access Status Not yet assessed
Volume 22
Issue 8
Start page 828
End page 838
Total pages 11
Place of publication Cambridge, United Kingdom
Publisher Cambridge University Press
Collection year 2017
Language eng
Formatted abstract
Background: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently described life-threatening autoimmune disorder associated with a characteristic multi-stage neuropsychiatric syndrome. Although it is known that the majority of patients experience neuropsychological disturbance post-treatment, some aspects of the cognitive profile remain unclear.

Methods: This study sought to investigate patterns of cognitive functioning in a sample of anti-NMDAR encephalitis patients. Seven (6F:1M; mean age, 26.4 years; range, 16-37 years) treated patients completed a comprehensive set of neurocognitive and social functioning measures. Performance was analyzed using normative data (where available), and comparison with matched controls (10F:4M; mean age, 25.8 years; range, 16-38 years).

Results: Individual cognitive profiles ranged from within normal limits to extensive dysfunction. Relative to controls, the patient group's performance was affected in the domains of verbal/ visual memory, working memory, attention, processing speed, executive functioning, and social cognition. The patient group also reported significantly higher levels of anxiety compared to controls.

Conclusions: These results add to the accumulating evidence that neurocognitive deficits, consistent with the distribution and functions of the NMDAR system can persist during recovery from anti-NMDAR encephalitis. This is the first study to provide evidence of performance decrements on measures of social cognition, including some involving theory of mind.
Keyword Anti-N-methyl-D-aspartate receptor encephalitis
Cognition disorders
Neuropsychology
Social behavior
Theory of mind
Treatment outcome
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 11 Oct 2016, 11:22:23 EST by System User on behalf of Learning and Research Services (UQ Library)