The impact of maternal hyper-oxygenation on foeto-placental blood flow

Prior, Tomas and Kumar, Sailesh (2016) The impact of maternal hyper-oxygenation on foeto-placental blood flow. Journal of Maternal-Fetal and Neonatal Medicine, 1-6. doi:10.1080/14767058.2016.1212009


Author Prior, Tomas
Kumar, Sailesh
Title The impact of maternal hyper-oxygenation on foeto-placental blood flow
Journal name Journal of Maternal-Fetal and Neonatal Medicine   Check publisher's open access policy
ISSN 1476-4954
1476-7058
Publication date 2016-09-23
Sub-type Article (original research)
DOI 10.1080/14767058.2016.1212009
Open Access Status Not yet assessed
Start page 1
End page 6
Total pages 6
Place of publication Abingdon, Oxfordshire, United Kingdom
Publisher Taylor & Francis
Collection year 2017
Language eng
Formatted abstract
Objective: Maternal hyperoxygenation has been reported to increase foetal oxygen saturation, and is frequently employed during intra-partum episodes of foetal compromise as a component of in utero resuscitation. However, there has been little investigation of its influence on foetal haemodynamics, particularly in appropriately grown foetuses.

Methods: This cohort study was undertaken between July 2013 and November 2013. All participants underwent an ultrasound scan prior to active labour (<4 cm dilated), during which foetal biometry, umbilical and middle cerebral artery Dopplers were recorded. Doppler measurements were then repeated after a 20-min period (to act as a control for subsequent measurements after oxygen therapy). Women were then asked to breathe 60% oxygen through Venturi valve masks for 20 min, after which the Doppler measurements were repeated.

Results: Twenty women were recruited to the study. No significant change in the foetal cerebro-umbilical (CU) ratio was observed following maternal oxygen therapy. The degree of change in Doppler parameters after oxygen therapy was not related to the baseline value of the Doppler parameter.

Conclusion: Maternal hyperoxygenation using 60% oxygen concentration over a 20-min period does not influence foetal umbilical or middle cerebral artery Doppler in appropriately grown foetuses. No adverse effects of maternal oxygen therapy were observed.
Keyword Foetal compromise
Foetal Doppler
Maternal hyperoxygenation
Oxygen therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Mater Research Institute-UQ (MRI-UQ)
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