Concise review: functional definition of endothelial progenitor cells: a molecular perspective

Patel, Jatin, Donovan, Prudence and Khosrotehrani, Kiarash (2016) Concise review: functional definition of endothelial progenitor cells: a molecular perspective. Stem Cells Translational Medicine, 5 10: 1302-1306. doi:10.5966/sctm.2016-0066


Author Patel, Jatin
Donovan, Prudence
Khosrotehrani, Kiarash
Title Concise review: functional definition of endothelial progenitor cells: a molecular perspective
Journal name Stem Cells Translational Medicine   Check publisher's open access policy
ISSN 2157-6580
2157-6564
Publication date 2016-10-01
Sub-type Critical review of research, literature review, critical commentary
DOI 10.5966/sctm.2016-0066
Open Access Status Not yet assessed
Volume 5
Issue 10
Start page 1302
End page 1306
Total pages 5
Place of publication Durham, NC, United States
Publisher AlphaMed Press
Collection year 2017
Language eng
Abstract Since the discovery of endothelial progenitor cells (EPCs) almost 2 decades ago, there has been great hope in their use in treating chronic ischemic disease. Unfortunately, to date,manyof the clinical trials using EPCs have been hampered by the lack of clear definition of this cell population. Attributes of a progenitor population are self-renewal and multipotentiality. Major progress has been achieved moving from a definition of EPCs based on a candidate cell surface molecule to a functional definition based essentially on self-renewal hierarchy of endothelial colony-forming cells (ECFCs). More recent work has seized on this functional characterization to associate gene expression signatures with the self-renewal capacity of ECFCs. In particular, Notch signaling driving the quiescence of progenitors has been shown to be central to progenitor self-renewal. This new molecular definition has tremendous translational consequences, because progenitors have been shown to display greater vasculogenic potential. Also, this molecular definition of EPC self-renewal allows assessment of the quality of presumed EPC preparations. This promises to be the initial stage in progressing EPCs further into mainstream clinical use.
Keyword Angiogenesis
Endothelial
Progenitor
Vascular
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: UQ Centre for Clinical Research Publications
HERDC Pre-Audit
Admin Only - School of Medicine
School of Medicine Publications
UQ Diamantina Institute Publications
Admin Only - UQCCR
 
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