Altered structural connectome in adolescent socially isolated mice

Liu, Cirong, Li, Yonghui, Edwards, Timothy J., Kurniawan, Nyoman D., Richards, Linda J. and Jiang, Tianzi (2016) Altered structural connectome in adolescent socially isolated mice. NeuroImage, 139 259-270. doi:10.1016/j.neuroimage.2016.06.037


Author Liu, Cirong
Li, Yonghui
Edwards, Timothy J.
Kurniawan, Nyoman D.
Richards, Linda J.
Jiang, Tianzi
Title Altered structural connectome in adolescent socially isolated mice
Journal name NeuroImage   Check publisher's open access policy
ISSN 1095-9572
1053-8119
Publication date 2016-10-01
Sub-type Article (original research)
DOI 10.1016/j.neuroimage.2016.06.037
Open Access Status Not yet assessed
Volume 139
Start page 259
End page 270
Total pages 12
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2017
Language eng
Formatted abstract
Social experience is essential for adolescent development and plasticity of social animals. Deprivation of the experience by social isolation impairs white matter microstructures in the prefrontal cortex. However, the effect of social isolation may involve highly distributed brain networks, and therefore cannot be fully explained by a change of a single region. Here, we compared the connectomes of adolescent socially-isolated mice and normal-housed controls via diffusion magnetic resonance imaging. The isolated mice displayed an abnormal connectome, characterized by an increase in degree and reductions in measures such as modularity, small-worldness, and betweenness. The increase in degree was most evident in the dorsolateral orbitofrontal cortex, entorhinal cortex, and perirhinal cortex. In a connection-wise comparison, we revealed that most of the abnormal edges were inter-modular and inter-hemispheric connections of the dorsolateral orbitofrontal cortex. Further tractography-based analyses and histological examinations revealed microstructural changes in the forceps minor and lateral-cortical tracts that were associated with the dorsolateral orbitofrontal cortex. These changes of connectomes were correlated with fear memory deficits and hyper-locomotion activities induced by social isolation. Considering the key role of the orbitofrontal cortex in social behaviors, adolescent social isolation may primarily disrupt the orbitofrontal cortex and its neural pathways thereby contributing to an abnormal structural connectome.
Keyword Brain network
Connectome
Diffusion MRI
Orbitofrontal cortex
Social deprivation
Structural connectivity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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