The effect of different volumes of high-intensity interval training on proinsulin in participants with the metabolic syndrome: a randomised trial

Ramos, Joyce S., Dalleck, Lance C., Borrani, Fabio, Mallard, Alistair R., Clark, Bronwyn, Keating, Shelley E., Fassett, Robert G. and Coombes, Jeff S. (2016) The effect of different volumes of high-intensity interval training on proinsulin in participants with the metabolic syndrome: a randomised trial. Diabetologia, 59 11: 1-13. doi:10.1007/s00125-016-4064-7


Author Ramos, Joyce S.
Dalleck, Lance C.
Borrani, Fabio
Mallard, Alistair R.
Clark, Bronwyn
Keating, Shelley E.
Fassett, Robert G.
Coombes, Jeff S.
Title The effect of different volumes of high-intensity interval training on proinsulin in participants with the metabolic syndrome: a randomised trial
Journal name Diabetologia   Check publisher's open access policy
ISSN 0012-186X
1432-0428
Publication date 2016-08-01
Sub-type Article (original research)
DOI 10.1007/s00125-016-4064-7
Open Access Status Not yet assessed
Volume 59
Issue 11
Start page 1
End page 13
Total pages 13
Place of publication Heidelberg, Germany
Publisher Springer
Collection year 2017
Language eng
Formatted abstract
Aims/hypothesis The continuous demand for insulin in the face of insulin resistance, coupled with the glucolipotoxic environment associated with the metabolic syndrome (MetS), adversely affects the quality of insulin produced and secreted by the pancreatic beta cells. This is depicted by increased circulating intact proinsulin concentration, which is associated with increased MetS severity and risk of cardiovascular (CV) mortality. High-intensity interval training (HIIT) has been shown to reduce insulin resistance and other CV disease risk factors to a greater degree than moderate-intensity continuous training (MICT). We therefore aimed to investigate the impact of MICT and different volumes of HIIT on circulating intact proinsulin concentration.
Methods This was a substudy of the ‘Exercise in prevention of Metabolic Syndrome’ (EX-MET) multicentre trial. Sixty-six individuals with MetS were randomised to 16 weeks of: (1) MICT (n = 21, 30 min at 60–70% peak heart rate [HRpeak], five times/week); (2) 4HIIT (n = 22, 4 × 4 min bouts at 85–95% HRpeak, interspersed with 3 min of active recovery at 50–70% HRpeak, three times/week); or (3) 1HIIT (n = 23, 1 × 4 min bout at 85–95% HRpeak, three times/week). A subanalysis investigated the differential impact of these training programmes on intact proinsulin concentration in MetS individuals with type 2 diabetes (MICT, n = 6; 4HIIT, n = 9; 1HIIT, n = 12) and without type 2 diabetes (MICT, n = 15; 4HIIT, n = 13; 1HIIT, n = 11). Intact proinsulin, insulin and C-peptide concentrations were measured in duplicate via ELISA, following a 12 h fast, before and after the exercise programme. Fasting intact proinsulin concentration was also expressed relative to insulin and C-peptide concentrations.
Results Following the exercise training, there were no significant (p > 0.05) changes in fasting intact proinsulin concentration indices in all participants (pre- vs post-programme proinsulin, proinsulin:insulin, proinsulin:C-peptide: MICT 19% decrease, 6% increase, 4% increase; 4HIIT 19% decrease, 8% decrease, 11% decrease; 1HIIT 34% increase, 49% increase, 36% increase). In participants who did not have type 2 diabetes, only 4HIIT significantly (p < 0.05) reduced fasting intact proinsulin concentration indices from pre to post intervention (pre- vs post-programme proinsulin, proinsulin:insulin, proinsulin:C-peptide: 4HIIT 32% decrease, 26% decrease, 32% decrease, p < 0.05; 1HIIT, 14% increase, 32% increase, 16% increase, p > 0.05; MICT 27% decrease, 17% decrease, 11% decrease), with a group × time interaction effect, indicating a greater reduction in intact proinsulin indices following 4HIIT compared with MICT and 1HIIT. There were no significant (p > 0.05) changes in intact proinsulin concentration indices in participants with type 2 diabetes.
Conclusions/interpretation Higher-volume HIIT (4HIIT) improved insulin quality in MetS participants without type 2 diabetes.
Keyword Glycaemic control
Insulin resistance
Interval training
Pancreatic beta cell function
Proinsulin
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Published online 1 August 2016

 
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Created: Mon, 22 Aug 2016, 21:58:04 EST by Sandrine Ducrot on behalf of School of Human Movement and Nutrition Sciences