A compact laser imaging system for concurrent reflectance confocal microscopy and laser doppler flowmetry

Mowla, Alireza, Taimre, Thomas, Lim, Yah Leng, Bertling, Karl, Wilson, Stephen J., Prow, Tarl W. and Rakic, Aleksandar D. (2016) A compact laser imaging system for concurrent reflectance confocal microscopy and laser doppler flowmetry. IEEE Photonics Journal, 8 5: . doi:10.1109/JPHOT.2016.2599014


Author Mowla, Alireza
Taimre, Thomas
Lim, Yah Leng
Bertling, Karl
Wilson, Stephen J.
Prow, Tarl W.
Rakic, Aleksandar D.
Title A compact laser imaging system for concurrent reflectance confocal microscopy and laser doppler flowmetry
Journal name IEEE Photonics Journal   Check publisher's open access policy
ISSN 1943-0655
Publication date 2016-08-10
Sub-type Article (original research)
DOI 10.1109/JPHOT.2016.2599014
Open Access Status DOI
Volume 8
Issue 5
Total pages 6
Place of publication Piscataway, NJ, United States
Publisher Institute of Electrical and Electronics Engineers
Collection year 2017
Language eng
Abstract We propose a compact laser feedback interferometry imaging system for concurrent reflectance confocal microscopy and laser Doppler flowmetry. This system acquires both confocal reflectance and Doppler signals in a confocal architecture to image dynamic turbid media with higher contrast than a system operating in either modality, and is coherent in nature. In a confocal optical configuration, reflectance confocal microscopy provides information about scattering from within a small volume centered around the focal point of the confocal system, and laser Doppler flowmetry provides information about the velocity of moving scatterers within the same volume. Raster scanning the sample enables the concurrent creation of two images, containing independent information, from a well specified depth within the sample. Concurrent spatial mapping of these independent sensing modalities affords improvement in the capability of the imaging system by obtaining additional information from both morphological and functional features of the dynamic turbid medium, at depths penetrable by near-infrared lasers. We realize the idea using a laser feedback interferometry imaging system scanning a microfluidic channel which contains a dynamic turbid medium. We show the effectiveness of this integrated imager quantitatively through the improvement of the signal to background ratio of a combined (multiplication) image.
Keyword Laser feedback interferometry
Laser Doppler velocimetry
Confocal reflectance microscopy
Near-infrared laser imaging
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Early access article

 
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Created: Thu, 11 Aug 2016, 11:59:45 EST by Karl Bertling on behalf of School of Information Technol and Elec Engineering