Maintenance of peripheral tolerance to islet antigens

Hamilton-Williams, Emma E., Bergot, Anne-Sophie, Reeves, Peta L. S and Steptoe, Raymond J. (2016) Maintenance of peripheral tolerance to islet antigens. Journal of Autoimmunity, 72 118-125. doi:10.1016/j.jaut.2016.05.009


Author Hamilton-Williams, Emma E.
Bergot, Anne-Sophie
Reeves, Peta L. S
Steptoe, Raymond J.
Title Maintenance of peripheral tolerance to islet antigens
Journal name Journal of Autoimmunity   Check publisher's open access policy
ISSN 0896-8411
1095-9157
Publication date 2016-08-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.jaut.2016.05.009
Open Access Status Not Open Access
Volume 72
Start page 118
End page 125
Total pages 8
Place of publication London, United Kingdom
Publisher Academic Press
Collection year 2017
Language eng
Abstract Reestablishment of immune tolerance to the insulin-producing beta cells is the desired goal for type 1 diabetes (T1D) treatment and prevention. Immune tolerance to multiple islet antigens is defective in individuals with T1D, but the mechanisms involved are multifaceted and may involve loss of thymic and peripheral tolerance. In this review we discuss our current understanding of the varied mechanisms by which peripheral tolerance to islet antigens is maintained in healthy individuals where genetic protection from T1D is present and how this fails in those with genetic susceptibility to disease. Novel findings in regards to expression of neo-islet antigens, non-classical regulatory cell subsets and the impact of specific genetic variants on tolerance induction are discussed.
Keyword Tolerance
Regulatory T cells
Type 1 diabetes
Genetic susceptibility
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
 
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Created: Wed, 10 Aug 2016, 21:50:00 EST by Emma Hamilton-Williams on behalf of UQ Diamantina Institute