Genetic restriction of the serum factor mediating tolerance in trinitrochlorobenzene hypersensitivity

Noonan F.P. and Halliday W.J. (1980) Genetic restriction of the serum factor mediating tolerance in trinitrochlorobenzene hypersensitivity. Cellular Immunology, 50 1: 41-47. doi:10.1016/0008-8749(80)90004-0


Author Noonan F.P.
Halliday W.J.
Title Genetic restriction of the serum factor mediating tolerance in trinitrochlorobenzene hypersensitivity
Journal name Cellular Immunology   Check publisher's open access policy
ISSN 1090-2163
Publication date 1980-03-01
Sub-type Article (original research)
DOI 10.1016/0008-8749(80)90004-0
Volume 50
Issue 1
Start page 41
End page 47
Total pages 7
Subject 1307 Cell Biology
2403 Immunology
Abstract Serum of mice which are tolerant to trinitrochlorobenzene (picryl chloride) inhibited the expression of hapten-specific cell-mediated immunity in vivo (delayed-type hypersensitivity) and in vitro (leukocyte adherence inhibition). These effects have now been demonstrated in three strains of inbred mice with different H-2 genotypes; in these mice the phenomenon was restricted to syngeneic cell-serum combinations. The serum factor mediating the effects in CBA mice was absorbed by the corresponding anti-Ia antiserum and by the specific hapten. The factor, which is found in serum and is demonstrable both in vivo and in vitro, thus appears to be antigen-binding and to have Ia determinants of the major histocompatibility complex.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Citation counts: TR Web of Science Citation Count  Cited 13 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 9 times in Scopus Article | Citations
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