An electron microscopic study of giant cytosegresomes in acute liver injury due to heliotrine

Kerr J.F.R. (1969) An electron microscopic study of giant cytosegresomes in acute liver injury due to heliotrine. Pathology, 1 2: 83-94. doi:10.3109/00313026909061041


Author Kerr J.F.R.
Title An electron microscopic study of giant cytosegresomes in acute liver injury due to heliotrine
Journal name Pathology   Check publisher's open access policy
ISSN 0031-3025
Publication date 1969
Sub-type Article (original research)
DOI 10.3109/00313026909061041
Volume 1
Issue 2
Start page 83
End page 94
Total pages 12
Publisher Informa Healthcare
Subject 2734 Pathology and Forensic Medicine
Abstract Large, PAS-positive globules that develop in the cytoplasm of the liver parenchymal cells of rats poisoned with the pyrrolizidine alkaloid heliotrine were shown to have a heterogeneous structure when examined with the electron microscope. Some represent segregated areas of cytoplasmic degradation. Others do not contain remnants of organelles and are probably derived from endocytosis vacuoles. Large, composite bodies consisting of various combinations of homogeneous vacuoles and fragments of partially degraded cytoplasm were commonly seen. Many had clearly arisen by accretion of their diverse components in sequential, discrete steps. The findings are in accord with histochemical studies indicating that the globules are lysosomal in nature. Occasionally, small dense bodies were observed in the process of fusing with large vacuoles. This suggests that the globules acquire at least some of their digestive enzymes from pre-existing lysosomes.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 09 Aug 2016, 01:17:45 EST by System User