Cardiorespiratory fitness and risk of sudden cardiac death in men and women in the United States: a prospective evaluation from the aerobics center longitudinal study

Jimenez-Pavon, David, Artero, Enrique G., Lee, Duck-chul, Espana-Romero, Vanesa, Sui, Xuemei, Pate, Russell R., Church, Timothy S., Moreno, Luis A., Lavie, Carl J. and Blair, Steven N. (2016) Cardiorespiratory fitness and risk of sudden cardiac death in men and women in the United States: a prospective evaluation from the aerobics center longitudinal study. Mayo Clinic Proceedings, 91 7: 849-857. doi:10.1016/j.mayocp.2016.04.025


Author Jimenez-Pavon, David
Artero, Enrique G.
Lee, Duck-chul
Espana-Romero, Vanesa
Sui, Xuemei
Pate, Russell R.
Church, Timothy S.
Moreno, Luis A.
Lavie, Carl J.
Blair, Steven N.
Title Cardiorespiratory fitness and risk of sudden cardiac death in men and women in the United States: a prospective evaluation from the aerobics center longitudinal study
Journal name Mayo Clinic Proceedings   Check publisher's open access policy
ISSN 0025-6196
1942-5546
Publication date 2016-07
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.mayocp.2016.04.025
Open Access Status Not yet assessed
Volume 91
Issue 7
Start page 849
End page 857
Total pages 9
Place of publication New York, NY United States
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
Objectives

To examine the relation between cardiorespiratory fitness (CRF) and sudden cardiac death (SCD) in a large US adult population and to study the effects of hypertension, obesity, and health status on the relation of CRF with SCD.

Patients and Methods

A total of 55,456 individuals (mean age, 44.2 years; 13,507 women) from the Aerobics Center Longitudinal Study, a prospective observational investigation (from January 2, 1974, through December 31, 2002), were included. Cardiorespiratory fitness was assessed by a maximal treadmill test, and baseline assessment included an extensive set of measurements.

Results

There were 109 SCDs. An inverse risk of SCD was found across incremental CRF levels after adjusting for potential confounders. Participants with moderate and high CRF levels had 44% (hazard ratio, 0.56; 95% CI, 0.35-0.90) and 48% (hazard ratio, 0.52; 95% CI, 0.30-0.92) significantly lower risk of SCD, respectively, than did those with low CRF levels (P<.001). The risk of SCD decreased by 14% (hazard ratio, 0.86; 95% CI, 0.77-0.96) per 1-metabolic equivalent increase in the fully adjusted model. Hypertensive, overweight, or unhealthy individuals with moderate to high CRF levels had lower risks of SCD (ranging from 58% to 72% of lower risk) than did those with the same medical conditions and low CRF levels.

Conclusion

The risk of SCD in US men and women could be partially reduced by ensuring moderate to high levels of CRF independently of other risk factors and especially in those who are hypertensive, overweight, or unhealthy.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Admin Only - School of Medicine
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Google Scholar Search Google Scholar
Created: Sun, 07 Aug 2016, 00:38:54 EST by System User on behalf of School of Medicine