Sensory experience modifies feature map relationships in visual cortex

Cloherty, Shaun L., Hughes, Nicholas J., Hietanen, Markus A., Bhagavatula, Partha S., Goodhill, Geoffrey J. and Ibbotson, Michael R. (2016) Sensory experience modifies feature map relationships in visual cortex. eLife, 5 . doi:10.7554/eLife.13911


Author Cloherty, Shaun L.
Hughes, Nicholas J.
Hietanen, Markus A.
Bhagavatula, Partha S.
Goodhill, Geoffrey J.
Ibbotson, Michael R.
Title Sensory experience modifies feature map relationships in visual cortex
Journal name eLife   Check publisher's open access policy
ISSN 2050-084X
Publication date 2016-06-16
Year available 2016
Sub-type Article (original research)
DOI 10.7554/eLife.13911
Open Access Status DOI
Volume 5
Total pages 20
Place of publication Cambridge, United Kingdom
Publisher eLife Sciences Publications
Collection year 2017
Language eng
Abstract The extent to which brain structure is influenced by sensory input during development is a critical but controversial question. A paradigmatic system for studying this is the mammalian visual cortex. Maps of orientation preference (OP) and ocular dominance (OD) in the primary visual cortex of ferrets, cats and monkeys can be individually changed by altered visual input. However, the spatial relationship between OP and OD maps has appeared immutable. Using a computational model we predicted that biasing the visual input to orthogonal orientation in the two eyes should cause a shift of OP pinwheels towards the border of OD columns. We then confirmed this prediction by rearing cats wearing orthogonally oriented cylindrical lenses over each eye. Thus, the spatial relationship between OP and OD maps can be modified by visual experience, revealing a previously unknown degree of brain plasticity in response to sensory input.
Keyword Brain structure
Sensory input during development
Orientation preference (OP)
Ocular dominance (OD)
Primary visual cortex
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: School of Mathematics and Physics
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Queensland Brain Institute Publications
 
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