Annexin A6 regulates interleukin-2-mediated T-cell proliferation

Cornely, Rhea, Pollock, Abigail H., Rentero, Carles, Norris, Sarah E., Alvarez-Guaita, Anna, Grewal, Thomas, Mitchell, Todd, Enrich, Carlos, Moss, Stephen E., Parton, Robert G., Rossy, Jeremie and Gaus, Katharina (2016) Annexin A6 regulates interleukin-2-mediated T-cell proliferation. Immunology and Cell Biology, 94 6: 543-553. doi:10.1038/icb.2016.15


Author Cornely, Rhea
Pollock, Abigail H.
Rentero, Carles
Norris, Sarah E.
Alvarez-Guaita, Anna
Grewal, Thomas
Mitchell, Todd
Enrich, Carlos
Moss, Stephen E.
Parton, Robert G.
Rossy, Jeremie
Gaus, Katharina
Title Annexin A6 regulates interleukin-2-mediated T-cell proliferation
Journal name Immunology and Cell Biology   Check publisher's open access policy
ISSN 1440-1711
0818-9641
Publication date 2016-07-01
Year available 2016
Sub-type Article (original research)
DOI 10.1038/icb.2016.15
Open Access Status Not yet assessed
Volume 94
Issue 6
Start page 543
End page 553
Total pages 11
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2017
Language eng
Formatted abstract
Annexin A6 (AnxA6) has been implicated in cell signalling by contributing to the organisation of the plasma membrane. Here we examined whether AnxA6 regulates signalling and proliferation in T cells. We used a contact hypersensitivity model to immune challenge wild-type (WT) and AnxA6-/- mice and found that the in vivo proliferation of CD4+ T cells, but not CD8+ T cells, was impaired in AnxA6-/- relative to WT mice. However, T-cell migration and signalling through the T-cell receptor ex vivo was similar between T cells isolated from AnxA6-/- and WT mice. In contrast, interleukin-2 (IL-2) signalling was reduced in AnxA6-/- compared with WT T cells. Further, AnxA6-deficient T cells had reduced membrane order and cholesterol levels. Taken together, our data suggest that AnxA6 regulates IL-2 homeostasis and sensitivity in T cells by sustaining a lipid raft-like membrane environment.
Keyword Annexin A6 (AnxA6)
Cell signalling
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
 
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