Lower integrated muscle protein synthesis in masters compared with younger athletes

Doering, Thomas M., Jenkins, David G., Reaburn, Peter R., Borges, Nattai R., Hohmann, Erik and Phillips, Stuart M. (2016) Lower integrated muscle protein synthesis in masters compared with younger athletes. Medicine and Science in Sports and Exercise, 48 8: 1613-1618. doi:10.1249/MSS.0000000000000935


Author Doering, Thomas M.
Jenkins, David G.
Reaburn, Peter R.
Borges, Nattai R.
Hohmann, Erik
Phillips, Stuart M.
Title Lower integrated muscle protein synthesis in masters compared with younger athletes
Journal name Medicine and Science in Sports and Exercise   Check publisher's open access policy
ISSN 1530-0315
0195-9131
Publication date 2016-08-01
Year available 2016
Sub-type Article (original research)
DOI 10.1249/MSS.0000000000000935
Open Access Status Not Open Access
Volume 48
Issue 8
Start page 1613
End page 1618
Total pages 6
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Collection year 2017
Language eng
Formatted abstract
Purpose: The objective of this study is to compare the integrated muscle protein synthesis (MPS) rates of masters and younger triathletes over three consecutive days of intense endurance training. Recovery of cycling performance, after muscle-damaging running, was also compared between groups.

Methods: Five masters (age, 53 ± 2 yr; VO2max, 55.7 ± 6.9 mL·kg-1 min-1) and six younger (age, 27 ± 2 yr; VO2max, 62.3 ± 1.5 mL·kg-1 min-1) trained triathletes volunteered for the study. Baseline skeletal muscle and saliva were initially sampled, after which a 150-mL bolus of deuterium oxide (70%) was consumed. Participants then completed a 30-min downhill run; three 20-km cycling time trials (TT) were completed 10, 24, and 48 h after the run. Saliva was collected each morning, and skeletal muscle was again sampled 72 h after the run; both were used for MPS analysis. Diet was controlled throughout the study.

Results: Over 3 d, masters triathletes showed a significantly lower myofibrillar fractional synthetic rate (1.49% ± 0.12%·d-1) compared with the younger (1.70% ± 0.09%·d-1) triathletes (P = 0.009, d = 1.98). There was also a trend for masters triathletes to produce a slower cycle TT (-3.0%, d = 0.46) than younger triathletes (-1.4%, d = 0.29) at 10 h postrun in comparison with the baseline performance. The between-group comparison of change was moderate (d = 0.51), suggesting slower acute recovery among masters triathletes.

Conclusions: The present data show lower MPS rates in well-trained masters triathletes over 3 d of training, and this likely contributes to poorer muscle protein repair and remodeling. Furthermore, acute recovery of cycle TT performance tended to be poorer in the masters triathletes.
Keyword Aging
Muscle damage
Protein
Recovery
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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