Crim1 – a regulator of developmental organogenesis

Iyer, Swati, Pennisi, David J. and Piper, Michael (2016) Crim1 – a regulator of developmental organogenesis. Histology And Histopathology, 31 10: 1049-1057. doi:10.14670/HH-11-766

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Author Iyer, Swati
Pennisi, David J.
Piper, Michael
Title Crim1 – a regulator of developmental organogenesis
Journal name Histology And Histopathology   Check publisher's open access policy
ISSN 1699-5848
Publication date 2016
Year available 2016
Sub-type Article (original research)
DOI 10.14670/HH-11-766
Open Access Status File (Publisher version)
Volume 31
Issue 10
Start page 1049
End page 1057
Total pages 18
Place of publication Murcia, Spain
Publisher Universidad de Murcia * Departamento de Biologia Celular e Histologia
Collection year 2017
Language eng
Abstract The regulation of growth factor localization, availability and activity is critical during embryogenesis to ensure appropriate organogenesis. This process is regulated through the coordinated expression of growth factors and their cognate receptors, as well as via proteins that can bind, sequester or localize growth factors to distinct locations. One such protein is the transmembrane protein Crim1. This protein has been shown to be expressed broadly within the developing embryo, and to regulate organogenesis within the eye, kidney and placenta. Mechanistically, Crim1 has been revealed to mediate organogenesis via its interaction with growth factors including TGFβs, BMPs, VEGFs and PDFGs. More recently, Crim1 has been shown to influence cardiac development, providing further insights into the function of this protein. This review will provide an overview of the role of Crim1 in organogenesis, largely focusing on how this protein regulates growth factor signaling in the nascent heart. Moreover, we will address the challenges ahead relating to further elucidating how Crim1 functions during development.
Keyword Kidney
Neuron system
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
School of Biomedical Sciences Publications
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Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
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Created: Fri, 05 Aug 2016, 20:30:16 EST by Dr Michael Piper on behalf of School of Biomedical Sciences