Type 1 interferons and NK cells restrict gamma-herpesvirus lymph node infection

Lawler, Clara, Tan, Cindy S. E., Simas, J. Pedro and Stevenson, Philip G. (2016) Type 1 interferons and NK cells restrict gamma-herpesvirus lymph node infection. Journal of Virology, . doi:10.1128/JVI.01108-16

Author Lawler, Clara
Tan, Cindy S. E.
Simas, J. Pedro
Stevenson, Philip G.
Title Type 1 interferons and NK cells restrict gamma-herpesvirus lymph node infection
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
Publication date 2016-07-27
Year available 2016
Sub-type Article (original research)
DOI 10.1128/JVI.01108-16
Open Access Status Not Open Access
Total pages 41
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2017
Language eng
Abstract Gamma-herpesviruses establish persistent, systemic infections and cause cancers. Murid Herpesvirus-4 (MuHV-4) provides a unique window onto the early events of host colonization. It spreads via lymph nodes. While dendritic cells (DC) pass MuHV-4 to lymph node B cells, subcapsular sinus macrophages (SSM), which capture virions from the afferent lymph, restrict its spread. Understanding how this restriction works offers potential clues to a more comprehensive defence. Type I interferons (IFN-I) blocked SSM lytic infection and reduced lytic cycle-independent viral reporter gene expression. Plasmacytoid DC were not required; but neither were SSM the only source of IFN-I, as IFN-I blockade increased infection in both intact and SSM-depleted mice. NK cells restricted lytic SSM infection independently of IFN-I, and SSM-derived virions spread to the spleen only when IFN-I responses and NK cells were both lacking. Thus, multiple innate defences allowed SSM to adsorb virions from the afferent lymph with relative impunity. Enhancing IFN-I and NK cell recruitment could potentially also restrict DC infection and so improve infection control.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
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Created: Fri, 05 Aug 2016, 11:27:20 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences