Type 1 interferons and NK cells restrict gamma-herpesvirus lymph node infection

Lawler, Clara, Tan, Cindy S. E., Simas, J. Pedro and Stevenson, Philip G. (2016) Type 1 interferons and NK cells restrict gamma-herpesvirus lymph node infection. Journal of Virology, 90 20: 9046-9057. doi:10.1128/JVI.01108-16

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Author Lawler, Clara
Tan, Cindy S. E.
Simas, J. Pedro
Stevenson, Philip G.
Title Type 1 interferons and NK cells restrict gamma-herpesvirus lymph node infection
Journal name Journal of Virology   Check publisher's open access policy
ISSN 0022-538X
Publication date 2016-07-27
Year available 2016
Sub-type Article (original research)
DOI 10.1128/JVI.01108-16
Open Access Status File (Publisher version)
Volume 90
Issue 20
Start page 9046
End page 9057
Total pages 41
Place of publication Washington, DC, United States
Publisher American Society for Microbiology
Collection year 2017
Language eng
Abstract Gamma-herpesviruses establish persistent, systemic infections and cause cancers. Murid Herpesvirus-4 (MuHV-4) provides a unique window onto the early events of host colonization. It spreads via lymph nodes. While dendritic cells (DC) pass MuHV-4 to lymph node B cells, subcapsular sinus macrophages (SSM), which capture virions from the afferent lymph, restrict its spread. Understanding how this restriction works offers potential clues to a more comprehensive defence. Type I interferons (IFN-I) blocked SSM lytic infection and reduced lytic cycle-independent viral reporter gene expression. Plasmacytoid DC were not required; but neither were SSM the only source of IFN-I, as IFN-I blockade increased infection in both intact and SSM-depleted mice. NK cells restricted lytic SSM infection independently of IFN-I, and SSM-derived virions spread to the spleen only when IFN-I responses and NK cells were both lacking. Thus, multiple innate defences allowed SSM to adsorb virions from the afferent lymph with relative impunity. Enhancing IFN-I and NK cell recruitment could potentially also restrict DC infection and so improve infection control.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Fri, 05 Aug 2016, 11:27:20 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences