Characterization of a QTL region affecting clinical mastitis and protein yield on BTA6

Nilsen, H., Olsen, H. G., Hayes, B., Nome, T., Sehested, E., Svendsen, M., Meuwissen, T. H. E. and Lien, S. (2009) Characterization of a QTL region affecting clinical mastitis and protein yield on BTA6. Animal Genetics, 40 5: 701-712. doi:10.1111/j.1365-2052.2009.01908.x


Author Nilsen, H.
Olsen, H. G.
Hayes, B.
Nome, T.
Sehested, E.
Svendsen, M.
Meuwissen, T. H. E.
Lien, S.
Title Characterization of a QTL region affecting clinical mastitis and protein yield on BTA6
Journal name Animal Genetics   Check publisher's open access policy
ISSN 0268-9146
1365-2052
Publication date 2009-10
Sub-type Article (original research)
DOI 10.1111/j.1365-2052.2009.01908.x
Open Access Status Not yet assessed
Volume 40
Issue 5
Start page 701
End page 712
Total pages 12
Place of publication Chichester, West Sussex PO19 8QG United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Formatted abstract
Quantitative trait loci affecting clinical mastitis were detected and fine mapped to a narrow region on bovine chromosome 6 in the Norwegian Red cattle population. The region includes the casein gene cluster and several candidate genes thought to influence clinical mastitis. The most significant results were found for SNPs within the Mucin 7 gene. This gene encodes an antimicrobial peptide and constitutes part of the first line of defence for the mucosal immune system. Detection of long haplotypes extending several Mb may indicate that artificial selection has influenced the haplotype structures in the region. A search for selection sweeps supports this observation and coincides with association results found both by single SNP and haplotype analyses. Our analyses identified haplotypes carrying quantitative trait loci alleles associated with high protein yield and simultaneously fewer incidences of clinical mastitis. The fact that such haplotypes are found in relative high frequencies in Norwegian Red may reflect the combined breeding goal that is characterized by selection for both milk production and disease resistance. The identification of these haplotypes raises the possibility of overcoming the unfavourable genetic correlation between these traits through haplotype-assisted selection.
Keyword Cattle
Clinical mastitis
Haplotypes
Protein yield
QTL
Selection sweeps
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Alliance for Agriculture and Food Innovation
 
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