Genomic organization and transcript profiling of the bovine toll-like receptor gene cluster TLR6-TLR1-TLR10

Opsal, Monica Aa., Vage, Dag Inge, Hayes, Ben, Berget, Ingunn and Lien, Sigbjorn (2006) Genomic organization and transcript profiling of the bovine toll-like receptor gene cluster TLR6-TLR1-TLR10. Gene, 384 45-50. doi:10.1016/j.gene.2006.06.027


Author Opsal, Monica Aa.
Vage, Dag Inge
Hayes, Ben
Berget, Ingunn
Lien, Sigbjorn
Title Genomic organization and transcript profiling of the bovine toll-like receptor gene cluster TLR6-TLR1-TLR10
Formatted title
Genomic organization and transcript profiling of the bovine toll-like receptor gene cluster TLR6-TLR1-TLR10
Journal name Gene   Check publisher's open access policy
ISSN 0378-1119
1879-0038
Publication date 2006-12-15
Sub-type Article (original research)
DOI 10.1016/j.gene.2006.06.027
Open Access Status Not yet assessed
Volume 384
Start page 45
End page 50
Total pages 6
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Language eng
Formatted abstract
Toll-like receptors (TLRs) are a family of recognition receptors playing a crucial role in the innate immune system. Different combinations of TLRs are thought to be crucial for effective immune response, thus insight into the organization and expression of TLRs is important for understanding disease resistance. Mastitis is the most frequent and costly disease in dairy production, and the innate immune system is considered to be important in the first line defence against this disease. In the present paper we have characterized the genomic organization of TLR6-TLR1-TLR10 in a ∼ 50 kb region of bovine chromosome 6, including 5′-untranslated exons not previously described. A method for gene expression analysis was developed and used for transcription profiling of the three paralogous genes in different bovine tissues. The expression analysis showed similar expression profiles for TLR1 and TLR6, which indicate a co-regulation of these two genes in cattle. TLR10 had a different expression profile, pointing toward a stronger functional diversification compared to TLR1 and TLR6. The differences in expression are in accordance with the evolutionary history of this gene cluster, where TLR10 diverged from the common ancestral gene before the duplication event that created TLR1 and TLR6.
Keyword Cattle
Disease resistance
Gene expression
Mastitis
SNP
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Alliance for Agriculture and Food Innovation
 
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