Quantitative trait loci for clinical mastitis on chromosomes 2, 6, 14 and 20 in Norwegian Red cattle

Sodeland, M., Kent, M. P., Olsen, H. G., Opsal, M. A., Svendsen, M., Sehested, E., Hayes, B. J. and Lien, S. (2011) Quantitative trait loci for clinical mastitis on chromosomes 2, 6, 14 and 20 in Norwegian Red cattle. Animal Genetics, 42 5: 457-465. doi:10.1111/j.1365-2052.2010.02165.x

Author Sodeland, M.
Kent, M. P.
Olsen, H. G.
Opsal, M. A.
Svendsen, M.
Sehested, E.
Hayes, B. J.
Lien, S.
Title Quantitative trait loci for clinical mastitis on chromosomes 2, 6, 14 and 20 in Norwegian Red cattle
Journal name Animal Genetics   Check publisher's open access policy
ISSN 0268-9146
Publication date 2011-10
Year available 2011
Sub-type Article (original research)
DOI 10.1111/j.1365-2052.2010.02165.x
Open Access Status Not yet assessed
Volume 42
Issue 5
Start page 457
End page 465
Total pages 9
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract Mastitis is the most frequent and costly disease in dairy production and solutions leading to a reduction in the incidence of mastitis are highly demanded. Here a genome-wide association study was performed to identify polymorphisms affecting susceptibility to mastitis. Genotypes for 17 349 SNPs distributed across the 29 bovine autosomal chromosomes from a total of 2589 sires with 1 389 776 daughters with records on clinical mastitis were included in the analysis. Records of occurrence of clinical mastitis were divided into seven time periods in the first three lactations in order to identify quantitative trait loci affecting mastitis susceptibility in particular phases of lactation. The most convincing results from the association mapping were followed up and validated by a combined linkage disequilibrium and linkage analysis. The study revealed quantitative trait loci affecting occurrence of clinical mastitis in the periparturient period on chromosomes 2, 6 and 20 and a quantitative trait locus affecting occurrence of clinical mastitis in late lactation on chromosome 14. None of the quantitative trait loci for clinical mastitis detected in the study seemed to affect lactation average of somatic cell score. The SNPs highly associated with clinical mastitis lie near both the gene encoding interleukin 8 on chromosome 6 and the genes encoding the two interleukin 8 receptors on chromosome 2.
Keyword Clinical mastitis
Genome-wide association studies
Linkage disequilibrium linkage analysis
Norwegian Red cattle
Somatic cell score
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Agriculture and Food Sciences
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