Casein haplotypes and their association with milk production traits in Norwegian Red cattle

Nilsen, Heidi, Olsen, Hanne Gro, Hayes, Ben, Sehested, Erling, Svendsen, Morten, Nome, Torfinn, Meuwissen, Theo and Lien, Sigbjorn (2009) Casein haplotypes and their association with milk production traits in Norwegian Red cattle. Genetics Selection Evolution, 41 . doi:10.1186/1297-9686-41-24

Author Nilsen, Heidi
Olsen, Hanne Gro
Hayes, Ben
Sehested, Erling
Svendsen, Morten
Nome, Torfinn
Meuwissen, Theo
Lien, Sigbjorn
Title Casein haplotypes and their association with milk production traits in Norwegian Red cattle
Journal name Genetics Selection Evolution   Check publisher's open access policy
ISSN 0999-193X
Publication date 2009-02-20
Sub-type Article (original research)
DOI 10.1186/1297-9686-41-24
Open Access Status DOI
Volume 41
Total pages 12
Place of publication London, United Kingdom
Publisher BioMed Central
Language eng
Formatted abstract
A high resolution SNP map was constructed for the bovine casein region to identify haplotype structures and study associations with milk traits in Norwegian Red cattle. Our analyses suggest separation of the casein cluster into two haplotype blocks, one consisting of the CSN1S1, CSN2 and CSN1S2 genes and another one consisting of the CSN3 gene. Highly significant associations with both protein and milk yield were found for both single SNPs and haplotypes within the CSN1S1-CSN2-CSN1S2 haplotype block. In contrast, no significant association was found for single SNPs or haplotypes within the CSN3 block. Our results point towards CSN2 and CSN1S2 as the most likely loci harbouring the underlying causative DNA variation. In our study, the most significant results were found for the SNP CSN2-67 with the C allele consistently associated with both higher protein and milk yields. CSN2-67 calls a C to an A substitution at codon 67 in -casein gene resulting in histidine replacing proline in the amino acid sequence. This polymorphism determines the protein variants A1/B (CSN2-67 A allele) versus A2/A3 (CSN2-67 C allele). Other studies have suggested that a high consumption of A1/B milk may affect human health by increasing the risk of diabetes and heart diseases. Altogether these results argue for an increase in the frequency of the CSN2-67 C allele or haplotypes containing this allele in the Norwegian Red cattle population by selective breeding.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Alliance for Agriculture and Food Innovation
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 24 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 32 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Fri, 05 Aug 2016, 10:10:27 EST by System User on behalf of Learning and Research Services (UQ Library)