Validation of single nucleotide polymorphisms associated with milk production traits in dairy cattle

Chamberlain, A. J., Hayes, B. J., Savin, K., Bolormaa, S., McPartlan, H. C., Bowman, P. J., Van der Jagt, C., MacEachern, S. and Goddard, M. E. (2012) Validation of single nucleotide polymorphisms associated with milk production traits in dairy cattle. Journal of Dairy Science, 95 2: 864-875. doi:10.3168/jds.2010-3786


Author Chamberlain, A. J.
Hayes, B. J.
Savin, K.
Bolormaa, S.
McPartlan, H. C.
Bowman, P. J.
Van der Jagt, C.
MacEachern, S.
Goddard, M. E.
Title Validation of single nucleotide polymorphisms associated with milk production traits in dairy cattle
Journal name Journal of Dairy Science   Check publisher's open access policy
ISSN 0022-0302
1525-3198
Publication date 2012-02
Sub-type Article (original research)
DOI 10.3168/jds.2010-3786
Open Access Status Not yet assessed
Volume 95
Issue 2
Start page 864
End page 875
Total pages 12
Place of publication New York, United States
Publisher Elsevier
Language eng
Abstract Single nucleotide polymorphism (SNP) associations with milk production traits found to be significant in different screening experiments, including SNP in genes hypothesized to be in gene pathways affecting milk production, were tested in a validation population to confirm their association. In total, 423 SNP were genotyped across 411 Holstein bulls, and their association with 6 milk production traits-Australian Selection Index (indicating the profitability of an animal's milk production), protein, fat, and milk yields, and protein and fat composition-were tested using single SNP regressions. Seventy-two SNP were significantly associated with one or more of the traits; their effects were in the same direction as in the screening experiment and therefore their association was considered validated. An over-representation of SNP (43 of the 423) on chromosome 20 was observed, including a SNP in the growth hormone receptor gene previously published as having an association with protein composition and protein and milk yields. The association with protein composition was confirmed in this experiment, but not the association with protein and milk yields. A multiple SNP regression analysis for all SNP on chromosome 20 was performed for all 6 traits, which revealed that this mutation was not significantly associated with any of the milk production traits and that at least 2 other quantitative trait loci were present on chromosome 20.
Keyword Milk production
Single nucleotide polymorphism
Validation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Alliance for Agriculture and Food Innovation
 
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