A medial to lateral shift in premovement cortical activity in hemi-Parkinson's disease: Studies of event-related potentials and whole-scalp magneto encephalography

Cunnington, R. and Deecke, L. (2003). A medial to lateral shift in premovement cortical activity in hemi-Parkinson's disease: Studies of event-related potentials and whole-scalp magneto encephalography. In: Australian Journal of Psychology: The Abstracts of the 3rd Victorian Postgraduates in Psychology Conference. 3rd Victorian Postgraduates in Psychology Conference, RMIT University, Victoria, (15-15). 23 November 2002.


Author Cunnington, R.
Deecke, L.
Title of paper A medial to lateral shift in premovement cortical activity in hemi-Parkinson's disease: Studies of event-related potentials and whole-scalp magneto encephalography
Conference name 3rd Victorian Postgraduates in Psychology Conference
Conference location RMIT University, Victoria
Conference dates 23 November 2002
Proceedings title Australian Journal of Psychology: The Abstracts of the 3rd Victorian Postgraduates in Psychology Conference   Check publisher's open access policy
Journal name Australian Journal of Psychology   Check publisher's open access policy
Place of Publication Basingstoke, U.K.
Publisher Taylor and Francis
Publication Year 2003
Sub-type Published abstract
ISSN 0004-9530
Volume 55
Issue Supp. 1
Start page 15
End page 15
Total pages 1
Language eng
Abstract/Summary Cortical activity associated with voluntary movement is shifted from medial to lateral premotor areas in Parkinson's disease. This occurs bilaterally, even for unilateral movements. We have used both EEG and MEG to further investigate medial and lateral premotor activity in patients with hemi-Parkinson's disease, in whom basal ganglia impairment is most pronounced in one hemisphere. The CNV, recorded from 21 scalp positions in a Go/NoGo task, was maximal over central medial regions in control subjects. For hemi-Parkinson's disease subjects, activity was shifted more frontally, reduced in the midline and lateralised towards the side of greatest basal ganglia impairment. With 143 channel whole-scalp magneto encephalography (MEG) we are further examining asymmetries in supplementary motor/premotor cortical activity prior to self-paced voluntary movement. In preliminary results, one hemi-Parkinson's disease patient with predominantly left-side symptoms showed strong medial activity consistent with a dominant source in the left supplementary motor area (SMA). Three patients showed little medial activity, but early bilateral sources within lateral premotor cortex. Results suggest greater involvement of lateral premotor rather than the SMA prior to movement in Parkinson's disease and provide evidence for asymmetric function of the SMA in hemi- Parkinson's disease, with reduced activity on the side of greatest basal ganglia deficit.
Subjects 1701 Psychology
Keyword Psychology, Multidisciplinary
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown

 
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Created: Mon, 13 Aug 2007, 13:58:25 EST