A validated genome wide association study to breed cattle adapted to an environment altered by climate change

Hayes, Ben J., Bowman, Phil J., Chamberlain, Amanda J., Savin, Keith, van Tassell, Curt P., Sonstegard, Tad S. and Goddard, Mike E. (2009) A validated genome wide association study to breed cattle adapted to an environment altered by climate change. PLoS ONE, 4 8: . doi:10.1371/journal.pone.0006676


Author Hayes, Ben J.
Bowman, Phil J.
Chamberlain, Amanda J.
Savin, Keith
van Tassell, Curt P.
Sonstegard, Tad S.
Goddard, Mike E.
Title A validated genome wide association study to breed cattle adapted to an environment altered by climate change
Journal name PLoS ONE   Check publisher's open access policy
ISSN 1932-6203
Publication date 2009-08-18
Sub-type Article (original research)
DOI 10.1371/journal.pone.0006676
Open Access Status DOI
Volume 4
Issue 8
Total pages 8
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Language eng
Abstract Continued production of food in areas predicted to be most affected by climate change, such as dairy farming regions of Australia, will be a major challenge in coming decades. Along with rising temperatures and water shortages, scarcity of inputs such as high energy feeds is predicted. With the motivation of selecting cattle adapted to these changing environments, we conducted a genome wide association study to detect DNA markers (single nucleotide polymorphisms) associated with the sensitivity of milk production to environmental conditions. To do this we combined historical milk production and weather records with dense marker genotypes on dairy sires with many daughters milking across a wide range of production environments in Australia. Markers associated with sensitivity of milk production to feeding level and sensitivity of milk production to temperature humidity index on chromosome nine and twenty nine respectively were validated in two independent populations, one a different breed of cattle. As the extent of linkage disequilibrium across cattle breeds is limited, the underlying causative mutations have been mapped to a small genomic interval containing two promising candidate genes. The validated marker panels we have reported here will aid selection for high milk production under anticipated climate change scenarios, for example selection of sires whose daughters will be most productive at low levels of feeding.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Alliance for Agriculture and Food Innovation
 
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