The origin of selection signatures on bovine chromosome 6

Hayes, B. J., Lien, S., Nilsen, H., Olsen, H. G., Berg, P., Maceachern, S., Potter, S. and Meuwissen, T. H. E. (2008) The origin of selection signatures on bovine chromosome 6. Animal Genetics, 39 2: 105-111. doi:10.1111/j.1365-2052.2007.01683.x

Author Hayes, B. J.
Lien, S.
Nilsen, H.
Olsen, H. G.
Berg, P.
Maceachern, S.
Potter, S.
Meuwissen, T. H. E.
Title The origin of selection signatures on bovine chromosome 6
Journal name Animal Genetics   Check publisher's open access policy
ISSN 0268-9146
Publication date 2008-04
Sub-type Article (original research)
DOI 10.1111/j.1365-2052.2007.01683.x
Open Access Status Not yet assessed
Volume 39
Issue 2
Start page 105
End page 111
Total pages 7
Place of publication Chichester, West Sussex, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Abstract The extent and pattern of linkage disequilibrium (LD) between closely spaced markers contain information about population history, including past population size and selection history. Selection signatures can be identified by comparing the LD surrounding a putative selected allele at a locus to the putative non-selected allele. In livestock populations, locations of selection signatures identified in this way should be correlated with QTL affecting production traits, as the populations have been under strong artificial selection for these traits. We used a dense SNP map of bovine chromosome 6 to characterize the pattern of LD on this chromosome in Norwegian Red cattle, a breed which has been strongly selected for milk production. The pattern of LD was generally consistent with strong selection in regions containing QTL affecting milk production traits, including a strong selection signature in a region containing a mutation known to affect milk production. The results demonstrate that in livestock populations, the origin of selection signatures will often be QTL for livestock production traits, and illustrate the value of selection signatures in uncovering new mutations with potential effects on quantitative traits.
Keyword Linkage disequilibrium
Population history
Selection signatures
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Queensland Alliance for Agriculture and Food Innovation
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