Harnessing the immune system in acute myeloid leukaemia

Austin, Rebecca, Smyth, Mark J. and Lane, Steven W. (2016) Harnessing the immune system in acute myeloid leukaemia. Critical Reviews in Oncology/Hematology, 103 62-77. doi:10.1016/j.critrevonc.2016.04.020


Author Austin, Rebecca
Smyth, Mark J.
Lane, Steven W.
Title Harnessing the immune system in acute myeloid leukaemia
Journal name Critical Reviews in Oncology/Hematology   Check publisher's open access policy
ISSN 1879-0461
1040-8428
Publication date 2016-07-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.critrevonc.2016.04.020
Open Access Status Not yet assessed
Volume 103
Start page 62
End page 77
Total pages 16
Place of publication E Park, Shannon, Clare Ireland
Publisher Elsevier Ireland
Collection year 2017
Language eng
Abstract Acute myeloid leukaemia (AML) is an aggressive blood cancer caused by the proliferation of immature myeloid cells. The genetic abnormalities underlying AML affect signal transduction pathways, transcription factors and epigenetic modifiers. In solid tumours, it is emerging that the genetic landscape of the tumour has a direct effect on the anti-tumour immune responses and response to immunotherapeutic treatment. However, there remains little information as to whether genetic abnormalities affect anti-leukemic immune responses. This review discusses current knowledge of AML antigens and immune responses to AML with a particular focus on the role of T cells and natural killer cells. Understanding immune responses to AML has implications for the development and use of immunotherapies to treat AML patients with distinct genetic abnormalities.
Keyword Acute myeloid leukaemia
Cancer immunosurveillance
Immune checkpoints
Immune suppression
Immunoediting
Immunotherapy
Neo-antigens
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
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