Role of ultraviolet radiation in papillomavirus-induced disease

Uberoi, Aayushi, Yoshida, Satoshi, Frazer, Ian H., Pitot, Henry C. and Lambert, Paul F. (2016) Role of ultraviolet radiation in papillomavirus-induced disease. PLoS Pathogens, 12 5: . doi:10.1371/journal.ppat.1005664


Author Uberoi, Aayushi
Yoshida, Satoshi
Frazer, Ian H.
Pitot, Henry C.
Lambert, Paul F.
Title Role of ultraviolet radiation in papillomavirus-induced disease
Journal name PLoS Pathogens   Check publisher's open access policy
ISSN 1553-7374
1553-7366
Publication date 2016-05-31
Year available 2016
Sub-type Article (original research)
DOI 10.1371/journal.ppat.1005664
Open Access Status DOI
Volume 12
Issue 5
Total pages 21
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2017
Language eng
Abstract Human papillomaviruses are causally associated with 5% of human cancers. The recent discovery of a papillomavirus (MmuPV1) that infects laboratory mice provides unique opportunities to study the life cycle and pathogenesis of papillomaviruses in the context of a genetically manipulatable host organism. To date, MmuPV1-induced disease has been found largely to be restricted to severely immunodeficient strains of mice. In this study, we report that ultraviolet radiation (UVR), specifically UVB spectra, causes wild-type strains of mice to become highly susceptible to MmuPV1-induced disease. MmuPV1-infected mice treated with UVB develop warts that progress to squamous cell carcinoma. Our studies further indicate that UVB induces systemic immunosuppression in mice that correlates with susceptibility to MmuPV1-associated disease. These findings provide new insight into how MmuPV1 can be used to study the life cycle of papillomaviruses and their role in carcinogenesis, the role of host immunity in controlling papillomavirus-associated pathogenesis, and a basis for understanding in part the role of UVR in promoting HPV infection in humans.
Keyword Human papillomaviruses (HPVs)
Human cancers
Ultraviolet radiation (UVR)
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
UQ Diamantina Institute Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Sun, 31 Jul 2016, 00:20:24 EST by System User on behalf of Learning and Research Services (UQ Library)