The role of size in development of mucosal liposome-lipopeptide vaccine candidates against group A streptococcus

Ghaffar, Khairunnisa Abdul, Marasini, Nirmal, Giddam, Ashwini Kumar, Batzloff, Michael R., Good, Michael F., Skwarczynski, Mariusz and Toth, Istvan (2016) The role of size in development of mucosal liposome-lipopeptide vaccine candidates against group A streptococcus. Medicinal Chemistry, 12 . doi:10.2174/1573406412666160720093138


Author Ghaffar, Khairunnisa Abdul
Marasini, Nirmal
Giddam, Ashwini Kumar
Batzloff, Michael R.
Good, Michael F.
Skwarczynski, Mariusz
Toth, Istvan
Title The role of size in development of mucosal liposome-lipopeptide vaccine candidates against group A streptococcus
Journal name Medicinal Chemistry   Check publisher's open access policy
ISSN 1875-6638
1573-4064
Publication date 2016-07-19
Year available 2016
Sub-type Article (original research)
DOI 10.2174/1573406412666160720093138
Open Access Status Not yet assessed
Volume 12
Total pages 1
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2017
Language eng
Abstract Background: Group A streptococcus (GAS) is an exclusively human pathogenic bacteria. A delay in treatment of GAS infection often lead to severe diseases such as rheumatic heart disease which attributes to hundreds of thousands deaths annually. For the past few decades, the quest for a commercial GAS vaccine has been futile. Currently one of the most investigated strategies to develop vaccine against GAS includes the use of conserved epitopes from major virulent factor of GAS, M-protein. Methods: In this study, cationic liposomes of various sizes (70 nm to 1000 nm) were prepared with dimethyldioctadecylammonium bromide (DDAB) encapsulating lipopeptide bearing M-protein derived B-cell epitope (J14). Results: Smaller liposomes induced higher antibody titres, though the differences between groups were not statistically significant. Conclusion: Nonetheless, all mice which were immunized with liposome-lipopeptide delivery system elicited high levels of systemic (IgG) and mucosal antibodies (IgA), which were discernably higher than those induced with the help of commercial adjuvant (cholera toxin B subunit).
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Chemistry and Molecular Biosciences
 
Versions
Version Filter Type
Citation counts: Google Scholar Search Google Scholar
Created: Fri, 29 Jul 2016, 10:37:32 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences