Hepatic elimination of flowing substrates: The distributed model

Bass L., Robinson P. and Bracken A.J. (1978) Hepatic elimination of flowing substrates: The distributed model. Journal of Theoretical Biology, 72 1: 161-184. doi:10.1016/0022-5193(78)90023-1


Author Bass L.
Robinson P.
Bracken A.J.
Title Hepatic elimination of flowing substrates: The distributed model
Journal name Journal of Theoretical Biology   Check publisher's open access policy
ISSN 1095-8541
Publication date 1978-05-08
Sub-type Article (original research)
DOI 10.1016/0022-5193(78)90023-1
Volume 72
Issue 1
Start page 161
End page 184
Total pages 24
Subject 1100 Agricultural and Biological Sciences
Abstract An earlier model of hepatic elimination with functionally identical sinusoids is extended by introducing statistical distributions of enzyme contents per sinusoid and of blood flow per sinusoid, these being either uncorrelated or closely correlated. The steady-state theory of the resulting distributed model is developed, including methods of determining experimentally the coefficients of variation of the distributions. Such determinations are made on an illustrative experimental example. Quantitative predictions of expected effects of changes in blood flow are given, including one for which the undistributed model predicts a null effect. Shapes of the postulated distributions are discussed only in relation to observable effects. Effects of the distributions are compared with maximum possible effects of incomplete equilibration of substrate within each sinusoidal cross-section, and methods for distinguishing these effects from each other are outlined.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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