The pathogenesis of bovine ephemeral fever virus infection of adult mice

Young P.L. and Spradbrow P.B. (1981) The pathogenesis of bovine ephemeral fever virus infection of adult mice. Journal of Comparative Pathology, 91 3: 369-379. doi:10.1016/0021-9975(81)90007-4


Author Young P.L.
Spradbrow P.B.
Title The pathogenesis of bovine ephemeral fever virus infection of adult mice
Journal name Journal of Comparative Pathology   Check publisher's open access policy
ISSN 0021-9975
Publication date 1981
Sub-type Article (original research)
DOI 10.1016/0021-9975(81)90007-4
Volume 91
Issue 3
Start page 369
End page 379
Total pages 11
Subject 1103 Clinical Sciences
Abstract Infection of adult mice with small doses of neuro-virulent bovine ephemeral fever virus caused a rapidly fatal encephalitis, the course of which was largely unaffected by treatment with either cyclophosphamide or anti-lymphocyte serum. Athymic mice died earlier than their thymic littermates. Mice could be protected by treatment with defective virus before infection or by passive administration of antibody if given less than 48 h after infection. Taken together these results emphasize the important protective role of antibody present at the time of infection. Viral isolation and immuno-fluorescent studies showed that the virus is confined to the central nervous system. Regular infection of suckling and adult mice by extra-cerebral routes was not possible.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
Versions
Version Filter Type
Citation counts: Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Tue, 26 Jul 2016, 04:54:09 EST by System User