Resetting the epigenome for heart regeneration

Quaife-Ryan, Gregory A., Sim, Choon Boon, Porrello, Enzo R. and Hudson, James E. (2016) Resetting the epigenome for heart regeneration. Seminars in Cell and Developmental Biology, . doi:10.1016/j.semcdb.2015.12.021


Author Quaife-Ryan, Gregory A.
Sim, Choon Boon
Porrello, Enzo R.
Hudson, James E.
Title Resetting the epigenome for heart regeneration
Journal name Seminars in Cell and Developmental Biology   Check publisher's open access policy
ISSN 1096-3634
1084-9521
Publication date 2016-01-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.semcdb.2015.12.021
Open Access Status Not yet assessed
Total pages 12
Place of publication London, United Kingdom
Publisher Academic Press
Collection year 2017
Language eng
Abstract In contrast to adults, recent evidence suggests that neonatal mice are able to regenerate following cardiac injury. This regenerative capacity is reliant on robust induction of cardiomyocyte proliferation, which is required for faithful regeneration of the heart following injury. However, cardiac regenerative potential is lost as cardiomyocytes mature and permanently withdraw from the cell cycle shortly after birth. Recently, a handful of factors responsible for the regenerative disparity between the adult and neonatal heart have been identified, but the proliferative response of adult cardiomyocytes following modulation of these factors rarely reaches neonatal levels. The inefficient re-induction of proliferation in adult cardiomyocytes may be due to the epigenetic landscape, which drastically changes during cardiac development and maturation. In this review, we provide an overview of the role of epigenetic modifiers in developmental processes related to cardiac regeneration. We propose an epigenetic framework for heart regeneration whereby adult cardiomyocyte identity requires resetting to a neonatal-like state to facilitate cell cycle re-entry and regeneration following cardiac injury.
Keyword Cardiac development
Cardiomyocyte proliferation
Epigenetics
Heart regeneration
Reprogramming
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Biomedical Sciences Publications
 
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