Differential radiosensitivity of mouse embryonic neurons and glia in cell culture

Dambergs R. and Kidson C. (1977) Differential radiosensitivity of mouse embryonic neurons and glia in cell culture. Journal of Neuropathology and Experimental Neurology, 36 3: 576-585.

Author Dambergs R.
Kidson C.
Title Differential radiosensitivity of mouse embryonic neurons and glia in cell culture
Journal name Journal of Neuropathology and Experimental Neurology   Check publisher's open access policy
ISSN 1554-6578
Publication date 1977
Sub-type Article (original research)
Volume 36
Issue 3
Start page 576
End page 585
Total pages 10
Subject 2728 Clinical Neurology
2734 Pathology and Forensic Medicine
2804 Cellular and Molecular Neuroscience
2808 Neurology
2800 Neuroscience
Abstract The responses of neurons and glial cells to ultraviolet and γ-radiation were studied in cell cultures of embryonic mouse brains. A decrease in the ratio of glia to neurons occurred after both forms of irradiation. [3H]thymidine labelling followed by autoradiography revealed that all glia were capable of replication, whereas 70% of neurons were non-replicating under the conditions of the study. Ultraviolet radiation caused a decrease in the proportion of replicating neurons but did not affect the proportion of replicating glia, whereas γ-radiation caused a decrease in DNA replication in both cell types. Levels of ultraviolet radiation-induced unscheduled DNA synthesis were lower in neurons than in glia. It is concluded that sensitivity to both ionizing and ultraviolet radiation of neurons and glial cells in embryonic brain cultures is determined primarily by the capacity for and state of DNA replication. Neurons which have already reached the stage of terminal differentiation are more resistant than replicating neurons of glial cells.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 26 Jul 2016, 04:23:55 EST by System User