Toxic material from the tentacles of the cubomedusan Chironex fleckeri

Endean R. and Noble M. (1971) Toxic material from the tentacles of the cubomedusan Chironex fleckeri. Toxicon, 9 3: . doi:10.1016/0041-0101(71)90078-X


Author Endean R.
Noble M.
Title Toxic material from the tentacles of the cubomedusan Chironex fleckeri
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 1971
Sub-type Article (original research)
DOI 10.1016/0041-0101(71)90078-X
Volume 9
Issue 3
Total pages 1
Subject 3005 Toxicology
Abstract Toxic material, lethal to mice and rats, was extracted from the tentacles of Chironex fleckeri from which nematocysts had been previously removed. The tentacle toxin was inactivated by heating at 35° or by exposure to proteolytic enzymes. The hearts of rats injected with the toxin showed a decrease in amplitude of cardiac contractions, bradycardia and atrioventricular block. After a small initial rise the arterial blood pressure of injected rats showed a pronounced fall. Conduction in the sciatic nerve of rats or toads was blocked by the toxin. The toxin possessed hemolytic activity. The tentacle toxin elicited no direct activity on vertebrate or crustacean skeletal musculature and showed negligible dermonecrotic activity. In these and many other respects its pharmacological activity was markedly different from that exhibited by the toxin isolated from nematocysts.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 26 Jul 2016, 04:02:39 EST by System User