Laboratory Control of Anticonvulsant Dosage

Eadie M.J. (1974) Laboratory Control of Anticonvulsant Dosage. Drugs, 8 5: 386-397. doi:10.2165/00003495-197408050-00006


Author Eadie M.J.
Title Laboratory Control of Anticonvulsant Dosage
Journal name Drugs   Check publisher's open access policy
ISSN 1179-1950
Publication date 1974
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2165/00003495-197408050-00006
Volume 8
Issue 5
Start page 386
End page 397
Total pages 12
Subject 2736 Pharmacology (medical)
2307 Health, Toxicology and Mutagenesis
3005 Toxicology
Abstract The plasma levels of various anticonvulsant drugs provide a measure of their concentration in the brain, where they exert their effects in controlling epilepsy. Some anticonvulsant drugs form metabolites which are also active against epilepsy, and it is desirable to measure the plasma levels of these metabolites, as well as those of the primary drug, in order to obtain a guide to the potential adequacy of the drug treatment of a patient’s epilepsy. For many of the anticonvulsants, ranges of plasma drug (and metabolite) concentrations have been found which are associated with the greatest chance of controlling epilepsy without undue risk of the type of drug side-effect regarded as due to overdosage, although side-effects from idiosyncrasy to the drug may still occur. Measurement of plasma levels of anticonvulsants can provide useful information to the clinician when there is difficulty in controlling a patient’s epilepsy or when drug overdosage is suspected. In the early stages of treatment the measurements can indicate whether or not a potentially adequate anticonvulsant dosage has been given. In interpreting plasma anticonvulsant measurements, the clinician should be aware of the accuracy of the assay as carried out in his laboratory, the frequent tendency of patients not to take the prescribed doses of their anticonvulsants, and the possibility of plasma anticonvulsant levels being altered by drug interactions or the presence of intercurrent disease. In recent years there has been considerable interest in measuring the concentrations of anticonvulsant drugs in plasma and other biological fluids, and in applying the findings of these laboratory studies to the treatment of epilepsy in man. Such measurements are becoming a very desirable adjunct to the routine clinical care of the patient with epilepsy, and are transforming the treatment of the disorder from a largely empirical art to something more nearly approaching an exact science.
Keyword Anticonvulsants
Epilepsy
Laboratory control
Phenytoin
Plasma levels
Therapeutic levels
Toxic levels
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Scopus Import
 
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