An electron microscopic study of liver cell necrosis due to albitocin

Kerr J.F.R. (1970) An electron microscopic study of liver cell necrosis due to albitocin. Pathology, 2 4: 251-259.

Author Kerr J.F.R.
Title An electron microscopic study of liver cell necrosis due to albitocin
Journal name Pathology   Check publisher's open access policy
ISSN 1465-3931
Publication date 1970
Sub-type Article (original research)
Volume 2
Issue 4
Start page 251
End page 259
Total pages 9
Subject 2734 Pathology and Forensic Medicine
Abstract Liver cell necrosis produced in rats by injection of the triterpenoid glycoside albitocin was studied with the electron microscope. Coagulative necrosis was of two distinct types. The first was characterized by the presence of clumps of calcium-associated, electron-opaque granules in the matrix of mitochondria, the changes closely resembling those described in necrosis due to various other toxins. However, in the second, clumps of matrix granules were absent and the appearances were like those seen in ischaemic necrosis and in in vitro autolysis. It is probable that this second type of necrosis resulted from sinusoidal obstruction, which followed the development of the first type of necrosis in the peripheral parts of the lobules. Mitochondria1 abnormalities provided the best indication of the development of coagulative necrosis, but the findings cast doubt on the importance of calcium accumulation within mitochondria as a causative factor in the initiation of necrosis. Shrinkage necrosis involved cellular condensation followed by fission into multiple, membrane-bounded cytoplasmic fragments. Some of these were ingested by parenchymal cells and histiocytes. Others probably underwent a process akin to coagulative necrosis.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 26 Jul 2016, 02:47:30 EST by System User