Physico-chemical properties of barbituric acid derivatives: IV. Solubilities of 5,5-disubstituted barbituric acids in water

Prankerd R.J. and McKeown R.H. (1994) Physico-chemical properties of barbituric acid derivatives: IV. Solubilities of 5,5-disubstituted barbituric acids in water. International Journal of Pharmaceutics, 112 1: 1-15. doi:10.1016/0378-5173(94)90256-9


Author Prankerd R.J.
McKeown R.H.
Title Physico-chemical properties of barbituric acid derivatives: IV. Solubilities of 5,5-disubstituted barbituric acids in water
Journal name International Journal of Pharmaceutics   Check publisher's open access policy
ISSN 0378-5173
Publication date 1994-11-04
Sub-type Article (original research)
DOI 10.1016/0378-5173(94)90256-9
Volume 112
Issue 1
Start page 1
End page 15
Total pages 15
Subject 3003 Pharmaceutical Science
Abstract Solubilities at 25°C in 0.001 M HC1 were determined for a series of 29 barbituric acid derivatives with aliphatic or aromatic substituents. The range of solubilities spanned more than four orders of magnitude. Relationships between these solubilities and other structural and physico-chemical properties were investigated. The data were fitted to a predictive relationship between solubility (as dependent variable) and the melting points and partition coefficients first proposed by Yalkowsky. The predicted solubilities from this relationship were in very good agreement with the measured values for some derivatives. A few solubilities deviated significantly. Data for several 5-methyl substituted barbituric acid derivatives suggested that they are more hydrated in aqueous solution than the corresponding 5-ethyl derivatives.
Keyword Barbiturate
Hydration
Melting point
Partition coefficient
Solubility
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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