THE NATURE OF PIECEMEAL NECROSIS IN CHRONIC ACTIVE HEPATITIS

Kerr J.F.R., Searle J., Halliday W.J., Roberts I., Cooksley W.G.E., Halliday J.W., Holder L., Burnett W. and Powell L.W. (1979) THE NATURE OF PIECEMEAL NECROSIS IN CHRONIC ACTIVE HEPATITIS. The Lancet, 314 8147: 827-828. doi:10.1016/S0140-6736(79)92178-0


Author Kerr J.F.R.
Searle J.
Halliday W.J.
Roberts I.
Cooksley W.G.E.
Halliday J.W.
Holder L.
Burnett W.
Powell L.W.
Title THE NATURE OF PIECEMEAL NECROSIS IN CHRONIC ACTIVE HEPATITIS
Journal name The Lancet   Check publisher's open access policy
ISSN 0140-6736
Publication date 1979-10-20
Sub-type Article (original research)
DOI 10.1016/S0140-6736(79)92178-0
Volume 314
Issue 8147
Start page 827
End page 828
Total pages 2
Subject 2700 Medicine
Abstract On the basis of histological studies, it is proposed that the type of liver-cell death in piecemeal necrosis is apoptosis. The characteristic inconspicuousness of apoptosis explains why the mode of hepatocyte elimination in piecemeal necrosis has hitherto remained obscure. Cell-mediated immune attack induces apoptosis, not classical necrosis, and the occurrence of apoptosis in piecemeal necrosis links the observed morphological changes in chronic active hepatitis with the other evidence for an autoimmune pathogenesis. It is significant that apoptosis does not evoke inflammation or fibroplasia. In attempting to elucidate the cause of the fibrosis that accompanies progression to cirrhosis in chronic hepatitis, it may thus be more relevant to study the effect on fibroblasts of substances liberated during lymphocyte-hepatocyte interactions than the death of the hepatocytes.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Scopus Import
 
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Created: Tue, 26 Jul 2016, 02:38:31 EST by System User