Multi-elemental profiling of tibial and maxillary trabecular bone in ovariectomised rats

Han, Pingping, Lu, Shifeier, Zhou, Yinghong, Moromizato, Karine, Du, Zhibin, Friis, Thor and Xiao, Yin (2016) Multi-elemental profiling of tibial and maxillary trabecular bone in ovariectomised rats. International Journal of Molecular Sciences, 17 6: . doi:10.3390/ijms17060977


Author Han, Pingping
Lu, Shifeier
Zhou, Yinghong
Moromizato, Karine
Du, Zhibin
Friis, Thor
Xiao, Yin
Title Multi-elemental profiling of tibial and maxillary trabecular bone in ovariectomised rats
Journal name International Journal of Molecular Sciences   Check publisher's open access policy
ISSN 1422-0067
1661-6596
Publication date 2016-06-21
Year available 2016
Sub-type Article (original research)
DOI 10.3390/ijms17060977
Open Access Status DOI
Volume 17
Issue 6
Total pages 15
Place of publication Basel, Switzerland
Publisher M D P I AG
Collection year 2017
Language eng
Formatted abstract
Atomic minerals are the smallest components of bone and the content of Ca, being the most abundant mineral in bone, correlates strongly with the risk of osteoporosis. Postmenopausal women have a far greater risk of suffering from OP due to low Ca concentrations in their bones and this is associated with low bone mass and higher bone fracture rates. However, bone strength is determined not only by Ca level, but also a number of metallic and non-metallic elements in bone. Thus, in this study, the difference of metallic and non-metallic elements in ovariectomy-induced osteoporosis tibial and maxillary trabecular bone was investigated in comparison with sham operated normal bone by laser ablation inductively-coupled plasma mass spectrometry using a rat model. The results demonstrated that the average concentrations of 25Mg, 28Si, 39K, 47Ti, 56Fe, 59Co, 77Se, 88Sr, 137Ba, and 208Pb were generally higher in tibia than those in maxilla. Compared with the sham group, Ovariectomy induced more significant changes of these elements in tibia than maxilla, indicating tibial trabecular bones are more sensitive to changes of circulating estrogen. In addition, the concentrations of 28Si, 77Se, 208Pb, and Ca/P ratios were higher in tibia and maxilla in ovariectomised rats than those in normal bone at all time-points. The present study indicates that ovariectomy could significantly impact the element distribution and concentrations between tibia and maxilla.
Keyword LA-ICP-MS
Maxilla
Osteoporosis
Ovariectomised rats
Tibia
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Australian Institute for Bioengineering and Nanotechnology Publications
 
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