Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease

Zhou, Fusheng, Cao, Hongzhi, Zuo, Xianbo, Zhang, Tao, Zhang, Xiaoguang, Liu, Xiaomin, Xu, Ricong, Chen, Gang, Zhang, Yuanwei, Zheng, Xiaodong, Jin, Xin, Gao, Jinping, Mei, Junpu, Sheng, Yujun, Li, Qibin, Liang, Bo, Shen, Juan, Shen, Changbing, Jiang, Hui, Zhu, Caihong, Fan, Xing, Xu, Fengping, Yue, Min, Yin, Xianyong, Ye, Chen, Zhang, Cuicui, Liu, Xiao, Yu, Liang, Wu, Jinghua, Chen, Mengyun, Zhuang, Xuehan, Tang, Lili, Shao, Haojing, Wu, Longmao, Li, Jian, Xu, Yu, Zhang, Yijie, Zhao, Suli, Wang, Yu, Li, Ge, Xu, Hanshi, Zeng, Lei, Wang, Jianan, Bai, Mingzhou, Chen, Yanling, Chen, Wei, Kang, Tian, Wu, Yanyan, Xu, Xun, Zhu, Zhengwei, Cui, Yong, Wang, Zaixing, Yang, Chunjun, Wang, Peiguang, Xiang, Leihong, Chen, Xiang, Zhang, Anping, Gao, Xinghua, Zhang, Furen, Xu, Jinhua, Zheng, Min, Zheng, Jie, Zhang, Jianzhong, Yu, Xueqing, Li, Yingrui, Yang, Sen, Yang, Huanming, Wang, Jian, Liu, Jianjun, Hammarstrom, Lennart, Sun, Liangdan, Wang, Jun and Zhang, Xuejun (2016) Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease. Nature Genetics, 48 7: 740-746. doi:10.1038/ng.3576

Author Zhou, Fusheng
Cao, Hongzhi
Zuo, Xianbo
Zhang, Tao
Zhang, Xiaoguang
Liu, Xiaomin
Xu, Ricong
Chen, Gang
Zhang, Yuanwei
Zheng, Xiaodong
Jin, Xin
Gao, Jinping
Mei, Junpu
Sheng, Yujun
Li, Qibin
Liang, Bo
Shen, Juan
Shen, Changbing
Jiang, Hui
Zhu, Caihong
Fan, Xing
Xu, Fengping
Yue, Min
Yin, Xianyong
Ye, Chen
Zhang, Cuicui
Liu, Xiao
Yu, Liang
Wu, Jinghua
Chen, Mengyun
Zhuang, Xuehan
Tang, Lili
Shao, Haojing
Wu, Longmao
Li, Jian
Xu, Yu
Zhang, Yijie
Zhao, Suli
Wang, Yu
Li, Ge
Xu, Hanshi
Zeng, Lei
Wang, Jianan
Bai, Mingzhou
Chen, Yanling
Chen, Wei
Kang, Tian
Wu, Yanyan
Xu, Xun
Zhu, Zhengwei
Cui, Yong
Wang, Zaixing
Yang, Chunjun
Wang, Peiguang
Xiang, Leihong
Chen, Xiang
Zhang, Anping
Gao, Xinghua
Zhang, Furen
Xu, Jinhua
Zheng, Min
Zheng, Jie
Zhang, Jianzhong
Yu, Xueqing
Li, Yingrui
Yang, Sen
Yang, Huanming
Wang, Jian
Liu, Jianjun
Hammarstrom, Lennart
Sun, Liangdan
Wang, Jun
Zhang, Xuejun
Title Deep sequencing of the MHC region in the Chinese population contributes to studies of complex disease
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1546-1718
Publication date 2016-07-01
Year available 2016
Sub-type Article (original research)
DOI 10.1038/ng.3576
Open Access Status Not yet assessed
Volume 48
Issue 7
Start page 740
End page 746
Total pages 7
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Collection year 2017
Language eng
Formatted abstract
The human major histocompatibility complex (MHC) region has been shown to be associated with numerous diseases. However, it remains a challenge to pinpoint the causal variants for these associations because of the extreme complexity of the region. We thus sequenced the entire 5-Mb MHC region in 20,635 individuals of Han Chinese ancestry (10,689 controls and 9,946 patients with psoriasis) and constructed a Han-MHC database that includes both variants and HLA gene typing results of high accuracy. We further identified multiple independent new susceptibility loci in HLA-C, HLA-B, HLA-DPB1 and BTNL2 and an intergenic variant, rs118179173, associated with psoriasis and confirmed the well-established risk allele HLA-C06:02. We anticipate that our Han-MHC reference panel built by deep sequencing of a large number of samples will serve as a useful tool for investigating the role of the MHC region in a variety of diseases and thus advance understanding of the pathogenesis of these disorders.
Keyword Genetics research
Medical genetics
Major histocompatibility complex (MHC) region
Deep sequencing
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Institute for Molecular Bioscience - Publications
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