A novel approach to the nutrigenetics and nutrigenomics of obesity and weight management

Joffe, Yael T. and Houghton, Christine A. (2016) A novel approach to the nutrigenetics and nutrigenomics of obesity and weight management. Current Oncology Reports, 18 . doi:10.1007/s11912-016-0529-6


Author Joffe, Yael T.
Houghton, Christine A.
Title A novel approach to the nutrigenetics and nutrigenomics of obesity and weight management
Journal name Current Oncology Reports   Check publisher's open access policy
ISSN 1534-6269
1523-3790
Publication date 2016-07-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1007/s11912-016-0529-6
Open Access Status Not yet assessed
Volume 18
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Springer Healthcare
Collection year 2017
Language eng
Abstract Nutrigenetics and nutrigenomics, as well as diet and exercise, play an important role in the development and treatment of obesity and its comorbidities. If an individual’s susceptibility to becoming obese and their responsiveness to weight loss interventions are to be understood, then it needs to be addressed at a molecular and metabolic level, including genetic interaction. This review proposes a three-pillar approach to more fully comprehend the complexity of diet-gene interactions in obesity. Peroxisomal proliferating-activated receptor gamma (PPARG) and mitochondrial uncoupling protein-1 (UCP-1) are explored in detail. Illustrating how an understanding of nutritional biochemistry, nutrigenomics, and nutrigenetics may be the key to understanding differences observed in the obese phenotype that vary both within and across populations.
Keyword Nutrigenetics
Nutrigenomics
Nutritional biochemistry
Obesity
PPARG
UCP-1
Weight loss
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Human Movement and Nutrition Sciences Publications
 
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