A systematic review of randomized trials for the treatment of burning mouth syndrome

Kisely, Steve, Forbes, Malcolm, Sawyer, Emily, Black, Emma and Lalloo, Ratilal (2016) A systematic review of randomized trials for the treatment of burning mouth syndrome. Journal of Psychosomatic Research, 86 39-46. doi:10.1016/j.jpsychores.2016.05.001


Author Kisely, Steve
Forbes, Malcolm
Sawyer, Emily
Black, Emma
Lalloo, Ratilal
Title A systematic review of randomized trials for the treatment of burning mouth syndrome
Journal name Journal of Psychosomatic Research   Check publisher's open access policy
ISSN 1879-1360
0022-3999
Publication date 2016-07-01
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.jpsychores.2016.05.001
Open Access Status Not Open Access
Volume 86
Start page 39
End page 46
Total pages 8
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
Objectives: Burning mouth syndrome (BMS) is characterized by burning of the oral mucosa in the absence of underlying dental or medical causes. The results of previous systematic reviews have generally been equivocal. However, findings for most interventions are based on searches of 5-10 years ago. This study therefore updates previous searches of randomized controlled trials (RCTs) for pain as assessed by Visual Analogue Scales (VAS). Secondary outcomes included quality of life, mood, taste and salivary flow.

Methods: A search of MEDLINE and Embase up to 2016.

Results: 24 RCTs were identified. Meta-analyses were impossible because of wide variations in study method and quality. The commonest interventions were alpha-lipoic acid (ALA) (8 comparisons), capsaicin or an analogue (4 comparisons), clonazepam (3 comparisons) and psychotherapy (2 comparisons). ALA and capsaicin led to significantly greater improvements in VAS (4 studies each), as did clonazepam (all 3 studies), at up to two month follow-up. However, capsaicin led to prominent dyspepsia. Psychotherapy significantly improved outcomes in one study at two and 12 month follow-up. Catauma and tongue-protectors also showed promise (one study each). There were no significant differences in any of the secondary outcomes except in the one study of tongue protectors.

Conclusions: At least in some studies and for some outcomes, ALA, clonazepam, capsaicin and psychotherapy may show modest benefit in the first two months. However, these conclusions are limited by generally short follow-up periods, high study variability and low participant numbers. Further RCTs with follow-up of at least 12 months are indicated.
Keyword Burning mouth syndrome
Medically unexplained symptoms
Randomized controlled trials
Somatic symptom disorder
Stomatodynia
Therapy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
Admin Only - School of Medicine
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