Late ELISA testing in infants born to HIV-positive mothers

Puertolas, Mora V., Bolton, Michael T. and Steele, Russell W. (2016) Late ELISA testing in infants born to HIV-positive mothers. Clinical Pediatrics, 55 7: 673-676. doi:10.1177/0009922815601032


Author Puertolas, Mora V.
Bolton, Michael T.
Steele, Russell W.
Title Late ELISA testing in infants born to HIV-positive mothers
Journal name Clinical Pediatrics   Check publisher's open access policy
ISSN 1938-2707
0009-9228
Publication date 2016-06-01
Year available 2015
Sub-type Article (original research)
DOI 10.1177/0009922815601032
Open Access Status Not yet assessed
Volume 55
Issue 7
Start page 673
End page 676
Total pages 4
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Collection year 2017
Language eng
Abstract We present the case of a young boy who was born to a human immunodeficiency virus (HIV)-positive mother and originally found to be uninfected. Evidence-based guidelines were followed regarding the mother's prenatal and infant's postnatal care, including the avoidance of breast milk. HIV DNA polymerase chain reaction qualitative tests were obtained at birth, 6 weeks and 4 months, and were all negative. He also received 6 weeks of prophylactic zidovudine. Despite these measures, his health began to decline at 17 months of age and antibody and serology tests performed at this time confirmed HIV infection. Guidelines no longer recommend routine antibody testing at 18 months of age to confirm the absence of infection in exposed infants with a record of negative virology in the first year of life. Based on this case and others we propose that this test be added back to the national guidelines for the early detection and prompt treatment of HIV infection in infants born to HIV-positive mothers.
Keyword Acquired HIV
Congenital HIV
HIV in infants
HIV PCR
Perinatal HIV
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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