Blood gene expression studies in migraine: potential and caveats

Gerring, Zachary, Rodriguez-Acevedo, Astrid J., Powell, Joseph E., Griffiths, Lyn R., Montgomery, Grant W. and Nyholt, Dale R. (2016) Blood gene expression studies in migraine: potential and caveats. Cephalalgia, 36 7: 669-678. doi:10.1177/0333102416628463


Author Gerring, Zachary
Rodriguez-Acevedo, Astrid J.
Powell, Joseph E.
Griffiths, Lyn R.
Montgomery, Grant W.
Nyholt, Dale R.
Title Blood gene expression studies in migraine: potential and caveats
Journal name Cephalalgia   Check publisher's open access policy
ISSN 1468-2982
0333-1024
Publication date 2016-06-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1177/0333102416628463
Open Access Status Not yet assessed
Volume 36
Issue 7
Start page 669
End page 678
Total pages 10
Place of publication London, United Kingdom
Publisher Sage Publications
Collection year 2017
Language eng
Formatted abstract
Background: Global gene expression analysis may be used to obtain insights into the functional processes underlying migraine. However, there is a shortage of high-quality post-mortem brain tissue samples for genetic analysis. One approach is to use a more accessible tissue as a surrogate, such as peripheral blood.

Purpose: Discuss the benefits and caveats of blood genomic profiling in migraine and its potential application in the development of biomarkers of migraine susceptibility and outcome. Demonstrate the utility of blood-based expression profiles in migraine by analysing pilot Illumina HT-12 expression data from 76 (38 case, 38 control) whole-blood samples.

Conclusion: Current evidence suggests peripheral blood is a biologically valid substrate for genetic studies of migraine, and may be used to identify biomarkers and therapeutic pathways. Pilot blood gene expression data confirm that expression profiles significantly differ between migraine case and non-migraine control individuals.
Keyword Association
Biomarkers
Blood
Expression
Gene
Genomic profiling
Migraine
MRNA
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Queensland Brain Institute Publications
Institute for Molecular Bioscience - Publications
 
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