Methicillin-resistant Staphylococcus aureus nasal colonization in Chinese children: a prevalence meta-analysis and review of influencing factors

Lin, Jialing, Peng, Yang, Xu, Ping, Zhang, Ting, Bai, Chan, Lin, Dongxin, Ou, Qianting and Yao, Zhenjiang (2016) Methicillin-resistant Staphylococcus aureus nasal colonization in Chinese children: a prevalence meta-analysis and review of influencing factors. PLoS One, 11 7: e0159728.1-e0159728.13. doi:10.1371/journal.pone.0159728


Author Lin, Jialing
Peng, Yang
Xu, Ping
Zhang, Ting
Bai, Chan
Lin, Dongxin
Ou, Qianting
Yao, Zhenjiang
Title Methicillin-resistant Staphylococcus aureus nasal colonization in Chinese children: a prevalence meta-analysis and review of influencing factors
Formatted title
Methicillin-resistant Staphylococcus aureus nasal colonization in Chinese children: a prevalence meta-analysis and review of influencing factors
Journal name PLoS One   Check publisher's open access policy
ISSN 1932-6203
Publication date 2016-07-21
Year available 2016
Sub-type Article (original research)
DOI 10.1371/journal.pone.0159728
Open Access Status DOI
Volume 11
Issue 7
Start page e0159728.1
End page e0159728.13
Total pages 13
Place of publication San Francisco, CA, United States
Publisher Public Library of Science
Collection year 2017
Language eng
Formatted abstract
Objective: To determine the pooled prevalence and review the influencing factors of methicillin-resistant Staphylococcus aureus (MRSA) nasal colonization in Chinese children.

Methods: Articles published between January 2005 and October 2015 that studied prevalence or influencing factors of MRSA nasal colonization in Chinese children were retrieved from Chinese Biomedical Literature database (CBM), China National Knowledge Infrastructure (CNKI) database, Chinese VIP database, Chinese Wanfang database, Medline database and Ovid database. Prevalence and influencing factors were analyzed by STATA 13.1.

Results: Thirteen articles were included. The overall prevalence of MRSA nasal colonization was 4.4% (95% confidence interval [CI]: 0.027–0.062). With an MRSA prevalence of 3.9% (95% CI: 0.018–0.061) in healthy children and 5.8% (95% CI: 0.025–0.092) in children with underlying medical conditions. Children recruited in the hospitals presented MRSA prevalence of 6.4% (95% CI: 0.037–0.091), which was higher than those recruited in the communities [2.7% (95% CI: 0.012–0.043)]. A number of influencing factors for MRSA nasal colonization were noted in three eligible studies: gender (male vs female; OR: 0.67; 95% CI: 0.55 0.82), younger age (OR: 2.98; 95% CI: 1.31–6.96 and OR: 1.56; 95% CI: 1.21–2.00), attending day care centers (OR: 2.97; 95% CI: 1.28–6.76), having infectious diseases (OR: 2.31; 95% CI: 1.10–4.52), using antibiotics (OR: 2.77; 95% CI: 1.45–5.05), residing in northern Taiwan (OR: 1.41; 95% CI: 1.15–1.71), passive smoking (OR: 1.30; 95% CI: 1.02–1.63), and pneumococcal vaccination (OR: 1.22; 95% CI: 1.01–1.48).

Conclusions: Children could act as reservoirs of MRSA transmissions. Hospitals remained the most frequent microorganism-circulated settings. More MRSA infection control strategies are required to prevent the dissemination among children.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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Created: Fri, 22 Jul 2016, 09:31:28 EST by Yang Peng on behalf of School of Medicine