Randomised clinical trial on the effect of a single oral administration of L-tryptophan, at three dose rates, on reaction speed, plasma concentration and haemolysis in horses

Noble, Glenys K., Li, Xiuhua, Zhang, Dagong and Sillence, Martin N. (2016) Randomised clinical trial on the effect of a single oral administration of L-tryptophan, at three dose rates, on reaction speed, plasma concentration and haemolysis in horses. Veterinary Journal, 213 84-86. doi:10.1016/j.tvjl.2016.05.003


Author Noble, Glenys K.
Li, Xiuhua
Zhang, Dagong
Sillence, Martin N.
Title Randomised clinical trial on the effect of a single oral administration of L-tryptophan, at three dose rates, on reaction speed, plasma concentration and haemolysis in horses
Journal name Veterinary Journal   Check publisher's open access policy
ISSN 1090-0233
1532-2971
Publication date 2016-07
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.tvjl.2016.05.003
Open Access Status Not Open Access
Volume 213
Start page 84
End page 86
Total pages 3
Place of publication London, United Kingdom
Publisher Elsevier
Collection year 2017
Language eng
Formatted abstract
Tryptophan (TRP) is marketed as a calmative for horses despite reservations about its efficacy. The aim of this study was to measure the effect of oral TRP administration on the reaction speed of horses. Sixty mature horses were used in a two stage randomised, blind, cross-over study, receiving a placebo and an oral dose of TRP (30, 60 or 120 mg/kg body weight), before undergoing a reaction speed test. Blood samples were taken up to 96 h after TRP administration, to identify signs of acute haemolytic anaemia. Plasma TRP concentrations were increased (P < 0.001) by the administration of TRP paste. However, TRP had no effect on the reaction speed of horses when startled. There was no evidence of alterations in clinical pathology parameters in 432 blood samples. While the safety of these doses of TRP can be confirmed, there was no evidence to suggest that a single dose of TRP is an effective calmative for horses.
Keyword Equine
Behaviour
Tryptophan
Reaction speed
Randomised clinical trial
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: HERDC Pre-Audit
School of Agriculture and Food Sciences
 
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