The impact of early-life exposure to air-borne environmental insults on the function of the airway epithelium in asthma

Spann, Kirsten, Snape, Natale, Baturcam, Engin and Fantino, Emmanuelle (2016) The impact of early-life exposure to air-borne environmental insults on the function of the airway epithelium in asthma. Annals of Global Health, 82 1: 28-40. doi:10.1016/j.aogh.2016.01.007


Author Spann, Kirsten
Snape, Natale
Baturcam, Engin
Fantino, Emmanuelle
Title The impact of early-life exposure to air-borne environmental insults on the function of the airway epithelium in asthma
Journal name Annals of Global Health   Check publisher's open access policy
ISSN 2214-9996
0027-2507
Publication date 2016-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.aogh.2016.01.007
Open Access Status DOI
Volume 82
Issue 1
Start page 28
End page 40
Total pages 13
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2017
Language eng
Abstract The airway epithelium is both a physical barrier protecting the airways from environmental insults and a significant component of the innate immune response. There is growing evidence that exposure of the airway epithelium to environmental insults in early life may lead to permanent changes in structure and function that underlie the development of asthma. Here we review the current published evidence concerning the link between asthma and epithelial damage within the airways and identify gaps in knowledge for future studies.
Keyword Asthma
Allergens
Air pollution
Virus
Epithelium
Early life
Airway remodeling
Immunity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Child Health Research Centre Publications
 
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