Vagal afferent innervation of the airways in health and disease

Mazzone, Stuart B. and Undem, Bradley J. (2016) Vagal afferent innervation of the airways in health and disease. Physiological Reviews, 96 3: 975-1024. doi:10.1152/physrev.00039.2015


Author Mazzone, Stuart B.
Undem, Bradley J.
Title Vagal afferent innervation of the airways in health and disease
Journal name Physiological Reviews   Check publisher's open access policy
ISSN 0031-9333
1522-1210
Publication date 2016-10
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1152/physrev.00039.2015
Open Access Status Not yet assessed
Volume 96
Issue 3
Start page 975
End page 1024
Total pages 50
Place of publication Bethesda, MD United States
Publisher American Physiological Society
Collection year 2017
Language eng
Abstract Vagal sensory neurons constitute the major afferent supply to the airways and lungs. Subsets of afferents are defined by their embryological origin, molecular profile, neurochemistry, functionality, and anatomical organization, and collectively these nerves are essential for the regulation of respiratory physiology and pulmonary defense through local responses and centrally mediated neural pathways. Mechanical and chemical activation of airway afferents depends on a myriad of ionic and receptor-mediated signaling, much of which has yet to be fully explored. Alterations in the sensitivity and neurochemical phenotype of vagal afferent nerves and/or the neural pathways that they innervate occur in a wide variety of pulmonary diseases, and as such, understanding the mechanisms of vagal sensory function and dysfunction may reveal novel therapeutic targets. In this comprehensive review we discuss historical and state-of-the-art concepts in airway sensory neurobiology and explore mechanisms underlying how vagal sensory pathways become dysfunctional in pathological conditions.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
School of Biomedical Sciences Publications
 
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