International genome-wide association study consortium identifies novel loci associated with blood pressure in children and adolescents

Parmar, Priyakumari Ganesh, Taal, H. Rob, Timpson, Nicholas J., Thiering, Elisabeth, Lehtimaki, Terho, Marinelli, Marcella, Lind, Penelope A., Howe, Laura D., Verwoert, Germaine, Aalto, Ville, Uitterlinden, Andre G., Briollais, Laurent, Evans, Dave M., Wright, Margie J., Newnham, John P., Whitfield, John B., Lyytikainen, Leo-Pekka, Rivadeneira, Fernando, Boomsma, Dorrett I., Viikari, Jorma, Gillman, Matthew W., St Pourcain, Beate, Hottenga, Jouke-Jan, Montgomery, Grant W., Hofman, Albert, Kahonen, Mika, Martin, Nicholas G., Tobin, Martin D., Raitakari, Ollie, Vioque, Jesus, Jaddoe, Vincent W. V., Jarvelin, Marjo-Riita, Beilin, Lawrence J., Heinrich, Joachim, van Duijn, Cornelia M., Pennell, Craig E., Lawlor, Debbie A. and Palmer, Lyle J. (2016) International genome-wide association study consortium identifies novel loci associated with blood pressure in children and adolescents. Circulation: Cardiovascular Genetics, 9 3: 266-278. doi:10.1161/CIRCGENETICS.115.001190

Author Parmar, Priyakumari Ganesh
Taal, H. Rob
Timpson, Nicholas J.
Thiering, Elisabeth
Lehtimaki, Terho
Marinelli, Marcella
Lind, Penelope A.
Howe, Laura D.
Verwoert, Germaine
Aalto, Ville
Uitterlinden, Andre G.
Briollais, Laurent
Evans, Dave M.
Wright, Margie J.
Newnham, John P.
Whitfield, John B.
Lyytikainen, Leo-Pekka
Rivadeneira, Fernando
Boomsma, Dorrett I.
Viikari, Jorma
Gillman, Matthew W.
St Pourcain, Beate
Hottenga, Jouke-Jan
Montgomery, Grant W.
Hofman, Albert
Kahonen, Mika
Martin, Nicholas G.
Tobin, Martin D.
Raitakari, Ollie
Vioque, Jesus
Jaddoe, Vincent W. V.
Jarvelin, Marjo-Riita
Beilin, Lawrence J.
Heinrich, Joachim
van Duijn, Cornelia M.
Pennell, Craig E.
Lawlor, Debbie A.
Palmer, Lyle J.
Title International genome-wide association study consortium identifies novel loci associated with blood pressure in children and adolescents
Journal name Circulation: Cardiovascular Genetics   Check publisher's open access policy
ISSN 1942-325X
Publication date 2016-06
Sub-type Article (original research)
DOI 10.1161/CIRCGENETICS.115.001190
Open Access Status Not yet assessed
Volume 9
Issue 3
Start page 266
End page 278
Total pages 13
Place of publication New York, United States
Publisher Lippincott Williams & Wilkins
Collection year 2017
Language eng
Formatted abstract
Background—Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence.

Methods and Results—Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4–7 years), puberty (8–12 years), and postpuberty (13–20 years). Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5′-C-phosphate-G-3′ methylation site) during prepuberty (P=2.86×10–8) and rs872256 during puberty (P=8.67×10–9). Several single-nucleotide polymorphism clusters were also associated with childhood BP at P<5×10–3. Using a P value threshold of <5×10–3, we found some overlap in variants across the different age epochs within our study and between several single-nucleotide polymorphisms in any of the 3 epochs and adult BP-related single-nucleotide polymorphisms.

Conclusions—Our results suggest that genetic determinants of BP act from childhood, develop over the lifecourse, and show some evidence of age-specific effects.
Keyword Blood pressure
Genetic epidemiology
Genome-Wide Association Study
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
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UQ Diamantina Institute Publications
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