Early-life exposure to widespread environmental toxicants and health risk: a focus on the immune and respiratory systems

Cao, Junjun, Xu, Xijin, Hylkema, Machteld N., Zeng, Eddy Y., Sly, Peter D., Suk, William A., Bergman, Ake and Huo, Xia (2016) Early-life exposure to widespread environmental toxicants and health risk: a focus on the immune and respiratory systems. Annals of Global Health, 82 1: 119-131. doi:10.1016/j.aogh.2016.01.023


Author Cao, Junjun
Xu, Xijin
Hylkema, Machteld N.
Zeng, Eddy Y.
Sly, Peter D.
Suk, William A.
Bergman, Ake
Huo, Xia
Title Early-life exposure to widespread environmental toxicants and health risk: a focus on the immune and respiratory systems
Journal name Annals of Global Health   Check publisher's open access policy
ISSN 2214-9996
0027-2507
Publication date 2016-01
Year available 2016
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.aogh.2016.01.023
Open Access Status DOI
Volume 82
Issue 1
Start page 119
End page 131
Total pages 13
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2017
Language eng
Abstract Evidence has accumulated that exposure to widespread environmental toxicants, such as heavy metals, persistent organic pollutants, and tobacco smoke adversely affect fetal development and organ maturation, even after birth. The developing immune and respiratory systems are more sensitive to environmental toxicants due to their long-term physical development, starting from the early embryonic stage and persisting into early postnatal life, which requires complex signaling pathways that control proliferation and differentiation of highly heterogeneous cell types. In this review, we summarize the effect of early-life exposure to several widespread environmental toxicants on immune and lung development before and after birth, including the effects on immune cell counts, baseline characteristics of cell-mediated and humoral immunity, and alteration of lung structure and function in offspring. We also review evidence supporting the association between early-life exposure to environmental toxicants and risk for immune-related diseases and lung dysfunction in offspring in later life.
Keyword Early-life exposure
Heavy metals
Tobacco smoke
Persistent organic pollutants
Immune development
Lung
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: HERDC Pre-Audit
Child Health Research Centre Publications
 
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