Recent advances in self-assembled peptides: Implications for targeted drug delivery and vaccine engineering

Eskandari, Sharareh, Guerin, Thalia, Toth, Istvan and Stephenson, Rachel J. (2016) Recent advances in self-assembled peptides: Implications for targeted drug delivery and vaccine engineering. Advanced Drug Delivery Reviews, . doi:10.1016/j.addr.2016.06.013


Author Eskandari, Sharareh
Guerin, Thalia
Toth, Istvan
Stephenson, Rachel J.
Title Recent advances in self-assembled peptides: Implications for targeted drug delivery and vaccine engineering
Journal name Advanced Drug Delivery Reviews   Check publisher's open access policy
ISSN 0169-409X
1872-8294
Publication date 2016-06-26
Year available 2016
Sub-type Article (original research)
DOI 10.1016/j.addr.2016.06.013
Open Access Status Not Open Access
Total pages 19
Place of publication Amsterdam, Netherlands
Publisher Elsevier BV
Collection year 2017
Language eng
Formatted abstract
Self-assembled peptides have shown outstanding characteristics for vaccine delivery and drug targeting. Peptide molecules can be rationally designed to self-assemble into specific nanoarchitectures in response to changes in their assembly environment including: pH, temperature, ionic strength, and interactions between host (drug) and guest molecules. The resulting supramolecular nanostructures include nanovesicles, nanofibers, nanotubes, nanoribbons, and hydrogels and have a diverse range of mechanical and physicochemical properties. These molecules can be designed for cell-specific targeting by including adhesion ligands, receptor recognition ligands, or peptide-based antigens in their design, often in a multivalent display. Depending on their design, self-assembled peptide nanostructures have advantages in biocompatibility, stability against enzymatic degradation, encapsulation of hydrophobic drugs, sustained drug release, shear-thinning viscoelastic properties, and/or adjuvanting properties. These molecules can also act as intracellular transporters and respond to changes in the physiological environment. Furthermore, this class of materials has shown sequence- and structure-dependent impacts on the immune system that can be tailored to non-immunogenic for drug targeting, and immunogenic for vaccine delivery. This review explores self-assembled peptide nanostructures (beta sheets, alpha helices, peptide amphiphiles, amino acid pairing, elastin like polypeptides, cyclic peptides, short peptides, Fmoc peptides, and peptide hydrogels) and their application in vaccine delivery and drug targeting.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

 
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Created: Fri, 15 Jul 2016, 14:02:25 EST by Mrs Louise Nimwegen on behalf of School of Chemistry & Molecular Biosciences